Product image of Orlistat Teva (Orlistat) supplied by GNH India

Orlistat Teva

Active Ingredient:
Orlistat
Origin:
EU

Orlistat Teva (Orlistat)

Orlistat, the active ingredient in Orlistat Teva, is a lipase inhibitor presented as a tablet for oral use. It reduces dietary fat absorption and is used to aid weight management in adults and adolescents with obesity or overweight conditions.

GNH India supplies Orlistat Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Orlistat is a lipase‑inhibiting agent indicated for conditions related to excess body weight.

  • Obesity: supports weight loss when combined with a reduced‑calorie, low‑fat diet.
  • Overweight adults: helps maintain weight loss achieved through diet and lifestyle changes.
  • Overweight adolescents (≥12 years): assists in weight reduction when used with dietary counseling.

How It Works

  • Orlistat acts locally in the gastrointestinal tract by covalently binding to the active site of gastric and pancreatic lipases, inhibiting their ability to hydrolyze dietary triglycerides. This blockade prevents the breakdown and subsequent absorption of about 30% of ingested fat, which is then eliminated in the feces, leading to a net reduction in caloric intake.

Side Effects

Orlistat may cause gastrointestinal and nutritional adverse reactions.

Common Side Effects

  • Oily spotting on underwear or clothing.
  • Increased flatulence with discharge.
  • Fecal urgency or incontinence.
  • Abdominal cramping or pain.
  • Frequent, oily or loose stools.
  • Reduced absorption of fat‑soluble vitamins.

Serious or Rare Side Effects

  • Severe abdominal pain.
  • Acute liver injury.
  • Pancreatitis.
  • Allergic reactions such as rash, itching, or swelling.
  • Vitamin K deficiency leading to bleeding disorders.
  • Kidney stones.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient suitability and counsel on diet.

  • BMI assessment: confirm obesity or overweight status before prescribing.
  • Low‑fat diet: advise patients to limit dietary fat to ≤30 g per meal.
  • Vitamin monitoring: consider supplementation of vitamins A, D, E, K and monitor levels.
  • Contraindications: avoid use in patients with chronic malabsorption syndromes or cholestasis.
  • Pregnancy and lactation: not recommended during pregnancy or while breastfeeding.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Orlistat can affect the absorption of several concomitant medications.

Major Interactions (Avoid)

  • Cyclosporine: reduced systemic exposure may compromise immunosuppression.
  • Levothyroxine: decreased absorption can lead to sub‑therapeutic thyroid levels.
  • Warfarin: altered vitamin K absorption may increase anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy; advise additional non‑hormonal contraception.
  • Anticonvulsants (e.g., carbamazepine): possible decreased absorption; monitor seizure control.
  • Fat‑soluble vitamin supplements: timing should be separated by at least 2 hours to avoid reduced uptake.

Frequently Asked Questions

Orlistat Teva is indicated for the management of obesity and overweight in adults and adolescents when used together with a reduced‑calorie, low‑fat diet. It helps patients achieve weight loss, maintain weight reduction, and improve related health outcomes such as blood pressure and lipid profiles.

Orlistat works by binding irreversibly to gastric and pancreatic lipases in the gastrointestinal tract. This inhibition prevents the enzymatic breakdown of dietary triglycerides, reducing fat absorption by about 30 % and allowing the unabsorbed fat to be excreted, thereby lowering overall caloric intake.

The prescribed dose of Orlistat Teva is determined by the treating clinician based on the patient’s weight, dietary plan, and therapeutic goals. Typically, the medication is taken with each main meal containing fat, but the exact regimen should follow the prescriber’s instructions.

Orlistat is not recommended for use during pregnancy or while breastfeeding because its safety profile has not been established for these populations. Women who are pregnant, planning to become pregnant, or nursing should discuss alternative weight‑management strategies with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Orlistat Teva. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and import documentation.

Unlike appetite‑suppressing agents, Orlistat works peripherally by blocking dietary fat absorption rather than affecting central nervous system pathways. This mechanism results in a distinct side‑effect profile, primarily gastrointestinal, and makes it suitable for patients who prefer a non‑systemic approach to weight management.

Orlistat Teva should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain product stability.

Orlistat Teva is taken orally with each main meal that contains fat, usually as a single tablet per meal. If a meal is missed or contains no fat, the dose may be omitted. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks, though rare, include acute liver injury, severe abdominal pain, pancreatitis, and allergic reactions such as rash or swelling. Patients should seek immediate medical attention if they experience any of these symptoms while using Orlistat.

Orlistat Teva is contraindicated in individuals with chronic malabsorption syndrome, cholestasis, or known hypersensitivity to the drug. It should also be avoided by pregnant or breastfeeding women and by patients taking medications that require consistent fat absorption without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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