Product image of Ornibel (Ethinylestradiol, Etonogestrel) supplied by GNH India

Ornibel

Active Ingredient:
Ethinylestradiol, Etonogestrel
Origin:
EU

Ornibel (Ethinylestradiol, Etonogestrel)

Ethinylestradiol, the active ingredient in Ornibel, is a combined hormonal contraceptive presented as a vaginal ring for intravaginal use. It works together with etonogestrel to prevent pregnancy by suppressing ovulation, thickening cervical mucus, and stabilizing the endometrium in women of reproductive age.

GNH India supplies Ornibel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets.

Manufacturer / TM Owner

Exeltis Healthcare S.L

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ornibel, a combined hormonal contraceptive, is used to prevent pregnancy by acting on the reproductive hormonal pathway.

  • Contraception: prevents pregnancy in women of reproductive age.
  • Ovulation suppression: inhibits the mid‑cycle luteinizing hormone surge.
  • Endometrial alteration: maintains a thin endometrium to reduce the chance of implantation.

How It Works

  • Ornibel delivers ethinylestradiol, a synthetic estrogen, and etonogestrel, a progestin, via a vaginal ring that releases the hormones continuously. Ethinylestradiol binds to estrogen receptors, providing negative feedback on the hypothalamic‑pituitary‑ovarian axis, while etonogestrel activates progesterone receptors, suppressing the luteinizing hormone surge and preventing follicular development. The combined effect also thickens cervical mucus and alters the endometrium, creating multiple barriers to fertilisation and implantation.

Side Effects

Ornibel may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient tension‑type headaches.
  • Breast tenderness: mild discomfort or swelling.
  • Irregular bleeding: spotting or breakthrough bleeding.
  • Mood changes: mild emotional fluctuations.
  • Weight gain: modest increase in body weight.

Serious or Rare Side Effects

  • Deep vein thrombosis: blood clot formation in deep veins.
  • Pulmonary embolism: clot migration to lung arteries.
  • Stroke: cerebrovascular accident.
  • Myocardial infarction: heart attack.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Hepatic adenoma: benign liver tumor.

Precautions & Warnings

When prescribing Ornibel, clinicians should consider several safety precautions to minimise risk.

  • Contraindication: avoid in women with a history of thromboembolic disorders.
  • Smoking: do not use in women over 35 who smoke.
  • Cardiovascular disease: assess risk before initiating therapy.
  • Liver disease: use with caution in hepatic impairment.
  • Migraine with aura: contraindicated due to increased stroke risk.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Ornibel can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Antiepileptics: enzyme inducers (e.g., carbamazepine) may reduce hormone levels.
  • Rifampicin: decreases contraceptive efficacy.
  • St. John’s wort: herbal inducer that lowers hormone concentrations.

Moderate Interactions (Monitor Closely)

  • Antifungals: azoles (e.g., ketoconazole) may increase hormone levels.
  • Antibiotics: broad‑spectrum agents may have variable impact.
  • Protease inhibitors: may affect hormone metabolism.
  • Antidepressants: SSRIs may alter bleeding patterns.

Frequently Asked Questions

Ornibel is a combined hormonal contraceptive containing ethinylestradiol and etonogestrel, indicated for the prevention of pregnancy in women of reproductive age. It works via a vaginal ring that releases hormones continuously to suppress ovulation, thicken cervical mucus, and alter the endometrium, providing multiple mechanisms of birth control.

Ethinylestradiol is a synthetic estrogen that binds to estrogen receptors in the hypothalamus and pituitary, delivering negative feedback that reduces the secretion of gonadotropins (FSH and LH). This suppression prevents the mid‑cycle LH surge required for ovulation, thereby contributing to the contraceptive effect when combined with a progestin such as etonogestrel.

The dosage regimen for Ornibel is determined by the prescribing healthcare professional. Typically, the vaginal ring is inserted and left in place for a specified period (e.g., three weeks) followed by a ring‑free interval, but the exact schedule and duration are set by the clinician based on individual patient needs and regulatory guidance.

Ornibel is not intended for use during pregnancy; it is a contraceptive method designed to prevent pregnancy. If pregnancy occurs, the product should be discontinued. Regarding breastfeeding, combined hormonal contraceptives are generally not recommended during the early postpartum period, and a healthcare provider should evaluate the risks and benefits before prescribing.

To place an order for Ornibel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature requirements), and necessary import documentation.

Ornibel delivers its hormones via a vaginal ring, offering continuous low‑dose release and eliminating the need for daily oral dosing, which can improve adherence compared with traditional combined oral contraceptive pills. Efficacy, side‑effect profile, and contraindications are similar to other estrogen‑progestin products, but the delivery system may provide more stable hormone levels and fewer missed‑dose failures.

Ornibel should be stored at ambient temperature, preferably below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and avoid exposure to extreme heat or freezing conditions. Proper storage helps maintain the integrity of the hormone release mechanism throughout its shelf life.

Ornibel is provided as a flexible vaginal ring that is inserted into the upper vagina by the user or a healthcare professional. Once placed, the ring continuously releases ethinylestradiol and etonogestrel for the prescribed duration (commonly three weeks), after which it is removed and a ring‑free interval follows before a new ring is inserted.

The most serious risks of Ornibel include thromboembolic events such as deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction, particularly in women with pre‑existing risk factors (e.g., smoking, hypertension, or a history of clotting disorders). Rare hepatic tumors and severe allergic reactions may also occur, requiring immediate medical attention.

Ornibel is contraindicated in women with a history of venous or arterial thromboembolism, known or suspected estrogen‑dependent tumors, uncontrolled hypertension, active liver disease, or migraine with aura. It should also be avoided by smokers over 35 years of age and by individuals with known hypersensitivity to ethinylestradiol, etonogestrel, or any excipients in the ring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.