Product image of Orofar Ultra (Flurbiprofen) supplied by GNH India

Orofar Ultra

Active Ingredient:
Flurbiprofen
Origin:
EU

Orofar Ultra (Flurbiprofen)

Flurbiprofen, the active ingredient in Orofar Ultra, is a NSAID presented as an oral tablet for oral use. It is used to relieve pain and inflammation in conditions such as arthritis, postoperative discomfort, and dental pain, primarily in adult patients.

GNH India supplies Orofar Ultra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Flurbiprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.
  • Rheumatoid arthritis: alleviates joint pain, swelling and stiffness
  • Osteoarthritis: improves mobility and reduces chronic joint discomfort
  • Postoperative pain: provides short‑term analgesia after surgical procedures
  • Dental pain: eases pain and inflammation following dental extractions or procedures
  • Dysmenorrhea: lessens menstrual cramp pain

How It Works

  • Flurbiprofen exerts its anti‑inflammatory and analgesic effects by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition reduces the synthesis of prostaglandins and thromboxanes, mediators that promote inflammation, pain, and fever. The resultant decrease in prostaglandin levels leads to diminished peripheral sensitisation of nociceptors and reduced inflammatory exudate formation.

Side Effects

Flurbiprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dyspepsia or stomach upset
  • Nausea and occasional vomiting
  • Headache or mild dizziness
  • Transient rash or itching
  • Mild elevation of liver enzymes
  • Fluid retention or mild edema

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Severe renal impairment or acute kidney injury
  • Hepatotoxicity with marked liver enzyme rise
  • Anaphylactic or severe allergic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Cardiovascular events such as myocardial infarction

Precautions & Warnings

  • When prescribing Flurbiprofen, clinicians should consider several safety measures.
  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use
  • Monitor renal function: especially in elderly patients or those with pre‑existing kidney disease
  • Avoid in patients with known hypersensitivity to flurbiprofen or other NSAIDs
  • Use caution with anticoagulants: increased risk of bleeding
  • Avoid in late pregnancy: potential fetal cardiovascular complications
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight

Avoid Interactions

Flurbiprofen can interact with a variety of medicines; awareness of the interaction level guides management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity
  • Corticosteroids: increased ulceration potential
  • Lithium: elevated lithium serum concentrations
  • Methotrexate: reduced clearance leading to toxicity

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function
  • Diuretics: risk of renal impairment and electrolyte imbalance
  • Selective serotonin reuptake inhibitors: modest increase in bleeding tendency
  • Beta‑blockers: may blunt antihypertensive effect
  • Antidiabetic agents: potential alteration of glucose control

Frequently Asked Questions

Orofar Ultra contains flurbiprofen, an NSAID indicated for the relief of mild to moderate pain and inflammation. It is commonly prescribed for conditions such as rheumatoid arthritis, osteoarthritis, postoperative pain, dental pain, and dysmenorrhea, providing symptomatic improvement in adult patients.

Flurbiprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This blockade reduces the production of prostaglandins, which are key mediators of inflammation, pain, and fever, thereby decreasing peripheral sensitisation of pain receptors and limiting inflammatory swelling.

The specific dose of Orofar Ultra is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and individual risk factors. Typical adult dosing ranges for flurbiprofen are described in the product label, but the exact regimen should always follow the prescriber’s instructions.

Flurbiprofen is generally avoided during the third trimester of pregnancy because it may affect fetal cardiovascular function. Use during earlier stages should be considered only if the potential benefit outweighs the risk. Limited data are available for breastfeeding; caution is advised, and a healthcare professional should evaluate the need for therapy.

To place an order, submit an enquiry on the Orofar Ultra product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Flurbiprofen shares the core anti‑inflammatory mechanism of other NSAIDs such as ibuprofen and naproxen but is often noted for a slightly longer half‑life, which may allow less frequent dosing. Its potency in COX inhibition can provide effective pain control, yet the safety profile—including gastrointestinal and renal risks—remains comparable to other agents in the class.

Orofar Ultra tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with excessive heat or humidity to maintain stability.

Orofar Ultra is taken orally with a full glass of water. It may be taken with or without food, although taking it with meals can reduce the likelihood of gastrointestinal discomfort. Patients should follow the dosing schedule prescribed by their healthcare provider.

The most serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hepatotoxicity, and rare but life‑threatening allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of these events, especially if they have pre‑existing risk factors.

Orofar Ultra should be avoided in individuals with known hypersensitivity to flurbiprofen or any NSAID, those with active peptic ulcer disease, severe heart failure, uncontrolled hypertension, advanced renal or hepatic impairment, and in the third trimester of pregnancy. Consultation with a healthcare professional is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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