Product image of Oroperidys (Domperidone) supplied by GNH India

Oroperidys

Active Ingredient:
Domperidone
Origin:
EU

Oroperidys (Domperidone)

Domperidone, the active ingredient in Oroperidys, is a dopamine D2 receptor antagonist presented as a tablet for oral use. It treats nausea, vomiting, gastroparesis and functional dyspepsia in adults.

GNH India supplies Oroperidys as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pierre Fabre Medicament

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Indications & Clinical Uses

Domperidone acts on the gastrointestinal tract and the chemoreceptor trigger zone to improve motility and reduce emesis.

  • Nausea and vomiting: Reduces episodes of nausea and vomiting by enhancing gastric emptying.
  • Gastroparesis: Improves gastric emptying and relieves symptoms of delayed stomach emptying.
  • Functional dyspepsia: Alleviates upper abdominal discomfort and early satiety associated with dyspepsia.

How It Works

  • Domperidone selectively antagonises peripheral dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract. By blocking dopamine‑mediated inhibition, it increases the release of acetylcholine, thereby stimulating gastric motility, accelerating gastric emptying, and reducing the stimulus for nausea and vomiting.

Side Effects

Domperidone is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Dry mouth: Reduced salivary secretion leading to a dry sensation.
  • Headache: Mild to moderate head pain.
  • Abdominal cramps: Discomfort or cramping in the stomach area.
  • Dizziness: Transient light‑headedness or vertigo.
  • Constipation: Decreased bowel movements.
  • Diarrhoea: Loose stools.

Serious or Rare Side Effects

  • Cardiac arrhythmia: Irregular heart rhythm, especially QT prolongation.
  • Extrapyramidal symptoms: Involuntary muscle movements or tremor.
  • Galactorrhoea: Unexpected milk production.
  • Severe allergic reaction: Rash, itching, swelling, or difficulty breathing.
  • Hyperprolactinaemia: Elevated prolactin levels causing hormonal effects.
  • QT interval prolongation: Potential for life‑threatening ventricular tachycardia.

Precautions & Warnings

Before prescribing Domperidone, clinicians should consider several safety aspects.

  • Cardiac assessment: Evaluate history of arrhythmia or prolonged QT interval.
  • Electrolyte monitoring: Check potassium and magnesium levels, especially in at‑risk patients.
  • Hepatic function: Use with caution in patients with liver impairment.
  • Concomitant QT‑prolonging drugs: Avoid co‑administration with other agents that lengthen the QT interval.
  • Elderly patients: Start at the lowest effective dose and monitor closely.
  • Store at room temperature: Keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Domperidone may interact with other medicines, altering its safety or effectiveness.

Major Interactions (Avoid)

  • Ketoconazole: Increases domperidone plasma levels, raising risk of cardiac toxicity.
  • Erythromycin or clarithromycin: Potentiate QT prolongation and cardiac risk.
  • Other QT‑prolonging agents (e.g., haloperidol): Heighten the chance of arrhythmias.
  • Cisapride: Combined effect on gastrointestinal motility and cardiac conduction.
  • Strong CYP3A4 inhibitors: Lead to elevated domperidone concentrations.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs: May reduce the pro‑kinetic effect of domperidone.
  • Other dopamine antagonists: Additive risk of extrapyramidal symptoms.
  • Fluconazole: Moderate CYP3A4 inhibition, may increase domperidone levels.
  • Antacids containing aluminium or magnesium: Can impair domperidone absorption if taken simultaneously.
  • Antihistamines: May enhance sedation or dizziness.

Frequently Asked Questions

Oroperidys contains domperidone, which is prescribed to manage nausea and vomiting, to treat gastroparesis by improving stomach emptying, and to relieve symptoms of functional dyspepsia such as early satiety and upper abdominal discomfort.

Domperidone works by selectively blocking peripheral dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract. This blockade lifts dopamine‑mediated inhibition, increasing acetylcholine release, which enhances gastric motility and reduces the neural signals that trigger nausea and vomiting.

The appropriate dose of Oroperidys is determined by the prescribing clinician based on the individual’s condition, age, renal and hepatic function, and other medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for domperidone in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional after a thorough risk‑benefit assessment.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other anti‑emetics such as metoclopramide, domperidone has limited central nervous system penetration, which reduces the risk of extrapyramidal side effects. However, both agents share the potential for QT prolongation, so cardiac risk assessment is essential for either medication.

Oroperidys should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain stability and potency throughout its shelf life.

Oroperidys is taken orally, usually with a glass of water. It can be taken with or without food, but patients should avoid taking it simultaneously with antacids containing aluminium or magnesium, as these may reduce its absorption.

The most serious risks include cardiac arrhythmias such as QT interval prolongation, which can lead to potentially fatal ventricular tachycardia, and rare extrapyramidal reactions. Patients with known cardiac disease or those taking other QT‑prolonging drugs should be monitored closely.

Oroperidys should be avoided in patients with known prolonged QT interval, significant cardiac arrhythmias, severe hepatic impairment, or in those concurrently using other strong CYP3A4 inhibitors or QT‑prolonging medications, unless a specialist determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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