Product image of Oropfen (Flurbiprofen) supplied by GNH India

Oropfen

Active Ingredient:
Flurbiprofen
Origin:
EU

Oropfen (Flurbiprofen)

Flurbiprofen, the active ingredient in Oropfen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It is employed to relieve pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis and acute musculoskeletal disorders, providing clinicians with a short‑term analgesic option and is indicated for short‑term therapy under medical supervision.

GNH India supplies Oropfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with established quality systems and regulatory approvals across the European market.

Manufacturer / TM Owner

Hemopharm Gmbh

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Indications & Clinical Uses

Flurbiprofen acts as an NSAID to reduce inflammation and pain in several musculoskeletal disorders.

  • Rheumatoid arthritis: reduces joint inflammation and pain.
  • Osteoarthritis: alleviates chronic joint discomfort.
  • Acute musculoskeletal pain: provides short‑term analgesia.

How It Works

  • Flurbiprofen inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes inflammation, pain, and fever at the site of tissue injury.

Side Effects

Adverse reactions may occur with flurbiprofen therapy.

Common Side Effects

  • Dyspepsia: stomach discomfort or indigestion.
  • Nausea: feeling of sickness or urge to vomit.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness.
  • Rash: mild skin irritation.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: potentially life‑threatening.
  • Renal impairment: reduced kidney function.
  • Hepatotoxicity: liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: acute allergic reaction requiring emergency care.

Precautions & Warnings

Before prescribing Oropfen, clinicians should consider several safety factors.

  • Assess renal function: monitor creatinine in patients with kidney disease.
  • Evaluate cardiovascular risk: avoid in uncontrolled hypertension or heart failure.
  • Review gastrointestinal history: use cautiously in patients with ulcer disease.
  • Avoid in late pregnancy: contraindicated during the third trimester.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Flurbiprofen can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible decline in renal function.
  • Diuretics: may reduce antihypertensive efficacy.
  • Lithium: NSAIDs may raise lithium serum levels.

Frequently Asked Questions

Oropfen contains flurbiprofen, an NSAID indicated for relief of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and acute musculoskeletal conditions. It is prescribed by healthcare professionals for short‑term management of moderate pain.

Flurbiprofen blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, reducing the synthesis of prostaglandins that mediate inflammation, pain, and fever. Lower prostaglandin levels lead to decreased swelling and discomfort at the affected site.

The dosage of Oropfen is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and any concomitant therapies. The prescriber sets the appropriate strength and frequency.

Flurbiprofen is generally avoided during the third trimester of pregnancy because of potential fetal cardiovascular effects, and it is not recommended for breastfeeding mothers unless the benefit outweighs the risk. Consultation with a healthcare provider is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Flurbiprofen has a relatively rapid onset of analgesia and potency comparable to ibuprofen, but its COX‑1 inhibition may confer a higher risk of gastrointestinal side effects than more COX‑2 selective agents such as celecoxib. Choice depends on efficacy, safety profile and patient factors.

Store Oropfen at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Oropfen is supplied as oral tablets that are taken by mouth with a full glass of water. It may be taken with or without food, although taking it with meals can reduce gastrointestinal discomfort.

The most serious adverse events include gastrointestinal ulceration or bleeding, severe renal impairment, hepatotoxicity, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome or anaphylaxis. Patients should seek immediate medical attention if they experience signs of these conditions.

Oropfen should be avoided in individuals with known hypersensitivity to flurbiprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, third‑trimester pregnancy, and in patients with significant renal or hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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