Product image of Orotre (Colecalciferol, Calcium Carbonate) supplied by GNH India

Orotre

Active Ingredient:
Colecalciferol, Calcium Carbonate
Origin:
EU

Orotre (Colecalciferol, Calcium Carbonate)

Colecalciferol, the active ingredient in Orotre, is a vitamin D3 supplement presented as an oral tablet containing calcium carbonate for combined supplementation. It helps correct vitamin D deficiency and supports calcium homeostasis in individuals at risk of low bone mineral density. The formulation is intended for oral use in adults and children as directed by a healthcare professional.

GNH India supplies Orotre as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Orotre, containing colecalciferol and calcium carbonate, is used to address disorders of vitamin D and calcium metabolism.

  • Vitamin D deficiency: restores normal serum 25‑hydroxyvitamin D levels.
  • Calcium deficiency: provides elemental calcium to support bone health.
  • Osteoporosis prevention: assists in maintaining bone mineral density in at‑risk populations.
  • Hypocalcemia: helps raise low blood calcium concentrations.

How It Works

  • Colecalciferol (vitamin D3) is metabolized in the liver and kidneys to the active hormone 1,25‑dihydroxyvitamin D, which binds to nuclear vitamin D receptors and enhances intestinal absorption of calcium and phosphate while modulating bone remodeling. Calcium carbonate supplies elemental calcium that is absorbed in the gastrointestinal tract, contributing to overall calcium homeostasis.

Side Effects

Common Side Effects

  • Nausea: mild stomach upset may occur.
  • Constipation: occasional difficulty passing stool.
  • Abdominal discomfort: mild cramps or pain.
  • Headache: transient head pain.
  • Dry mouth: sensation of oral dryness.
  • Flatulence: increased gas production.

Serious or Rare Side Effects

  • Hypercalcemia: elevated blood calcium levels causing weakness or cardiac arrhythmia.
  • Kidney stones: formation of calcium‑based calculi in the urinary tract.
  • Allergic reaction: rash, itching, swelling, or breathing difficulty.
  • Hypervitaminosis D: toxicity from excessive vitamin D leading to calcification of soft tissues.
  • Hypercalciuria: excessive urinary calcium excretion increasing renal risk.

Precautions & Warnings

Before using Orotre, consider the following precautions:

  • Pregnancy and lactation: consult a healthcare provider before use.
  • Renal impairment: monitor calcium levels and adjust intake as needed.
  • Existing hypercalcemia: avoid use if blood calcium is already elevated.
  • Drug interactions: review all concurrent medications with a professional.
  • Age considerations: dosage may differ for children and the elderly.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Orotre may interact with several medications. Review the following:

Major Interactions (Avoid)

  • Thiazide diuretics: can increase risk of hypercalcemia.
  • High-dose vitamin A supplements: may potentiate vitamin D toxicity.
  • Lithium therapy: may affect calcium metabolism.

Moderate Interactions (Monitor Closely)

  • Oral bisphosphonates: concurrent use may alter calcium balance.
  • Corticosteroids: may reduce calcium absorption, requiring monitoring.
  • Antacids containing aluminum or magnesium: can decrease calcium carbonate absorption.

Frequently Asked Questions

Orotre is a combined vitamin D3 (colecalciferol) and calcium carbonate oral tablet used to correct vitamin D deficiency, supplement calcium intake, and support overall bone health in individuals at risk of low bone mineral density.

Colecalciferol is converted in the liver and kidneys to the active hormone 1,25‑dihydroxyvitamin D, which binds to vitamin D receptors in target cells, enhancing intestinal absorption of calcium and phosphate and regulating bone remodeling processes.

The appropriate dose of Orotre is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, laboratory values, and overall nutritional needs. No standard regimen is provided here.

Use of Orotre during pregnancy or lactation should only occur under medical supervision. While vitamin D and calcium are essential nutrients, the prescriber must evaluate the risk‑benefit profile for each individual.

To order Orotre, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Orotre combines colecalciferol with calcium carbonate, offering both vitamin D and calcium in a single tablet. Stand‑alone vitamin D3 products provide only the hormone precursor, while separate calcium supplements lack the vitamin D component. The combination can simplify dosing for patients needing both nutrients.

Store Orotre tablets at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct light. Keep the container tightly closed and out of reach of children.

Orotre is taken orally, usually with a glass of water. It can be taken with or without food, but taking it with meals may improve calcium absorption. Follow the prescriber’s instructions regarding frequency and duration.

The most serious risks include hypercalcemia, hypervitaminosis D, kidney stone formation, and severe allergic reactions. Patients should be monitored for signs such as persistent nausea, vomiting, muscle weakness, or unusual fatigue, and seek medical attention if they occur.

Individuals with known hypersensitivity to colecalciferol, calcium carbonate, or any excipients, as well as patients with existing hypercalcemia, severe renal impairment, or certain metabolic disorders, should avoid Orotre unless a healthcare professional advises otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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