Product image of Orstanorm (Dihydroergotamine Mesilate) supplied by GNH India

Orstanorm

Active Ingredient:
Dihydroergotamine Mesilate
Origin:
EU

Orstanorm (Dihydroergotamine Mesilate)

Dihydroergotamine mesilate, the active ingredient in Orstanorm, is an ergot alkaloid presented as a tablet for oral use. It is employed to treat acute migraine attacks and, off‑label, cluster headaches in adult patients, providing rapid relief of severe headache symptoms.

GNH India supplies Orstanorm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with consistent quality and regulatory compliance.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

  • Orstanorm acts on the serotonergic and vascular pathways involved in primary headache disorders.
  • Acute migraine attacks: provides rapid relief of migraine pain and associated symptoms.
  • Cluster headache (off‑label): may reduce the frequency and intensity of cluster headache episodes.
  • Migraine with aura: helps abort the headache phase in patients experiencing visual or sensory aura preceding migraine.

How It Works

  • Dihydroergotamine mesilate binds as a partial agonist/antagonist to serotonergic 5‑HT1B/1D receptors, dopaminergic and alpha‑adrenergic receptors, causing vasoconstriction of intracranial vessels and inhibition of neurogenic inflammation, thereby alleviating migraine and related headache pain.

Side Effects

Orstanorm may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness or light‑headedness
  • Fatigue or weakness
  • Chest tightness or discomfort
  • Peripheral coldness or tingling

Serious or Rare Side Effects

  • Severe hypertension or hypertensive crisis
  • Myocardial ischemia or infarction
  • Cerebrovascular events such as stroke
  • Anaphylactic or severe allergic reactions
  • Serotonin syndrome when combined with serotonergic agents
  • Severe vasospasm leading to tissue necrosis

Precautions & Warnings

  • When prescribing Orstanorm, consider the following precautions to ensure safe use.
  • Assess cardiovascular status: evaluate for hypertension, coronary artery disease, or peripheral vascular disease before initiating therapy.
  • Avoid in uncontrolled hypertension: risk of severe vasoconstriction and hypertensive crisis.
  • Caution in cerebrovascular disease: potential to precipitate stroke.
  • Monitor for serotonin syndrome: especially when used with SSRIs, SNRIs, or triptans.
  • Store at ambient temperature: keep in the original packaging, protect from moisture.

Avoid Interactions

Orstanorm can interact with several medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • Other ergotamine‑containing products: additive vasoconstriction.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increased plasma concentrations.
  • Serotonergic agents (SSRIs, SNRIs, triptans): heightened risk of serotonin syndrome.
  • MAO inhibitors: amplified vasoconstrictive effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: possible reduction in blood‑pressure control.
  • Beta‑blockers: may enhance bradycardia or hypotensive effects.

Frequently Asked Questions

Orstanorm is prescribed to treat acute migraine attacks and, off‑label, to alleviate the frequency and severity of cluster headache episodes in adult patients.

Dihydroergotamine mesilate acts as a partial agonist/antagonist at serotonergic 5‑HT1B/1D, dopaminergic and alpha‑adrenergic receptors, producing vasoconstriction of intracranial vessels and reducing neurogenic inflammation, which helps relieve headache pain.

The specific dose of Orstanorm is determined by the prescribing healthcare professional based on the individual patient's condition, severity of symptoms, and clinical response.

Safety data for Orstanorm in pregnancy and lactation are limited; the pregnancy category is unknown, so it should only be used if the potential benefit justifies any potential risk to the fetus or infant.

To order Orstanorm, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Orstanorm (dihydroergotamine mesilate) belongs to the ergot alkaloid class, offering a rapid onset of action for acute migraine. Compared with triptans, it has a broader receptor profile and may be effective when triptans fail, but it carries a higher risk of vasoconstrictive side effects.

Orstanorm tablets should be stored at ambient temperature, below 25 °C, in their original packaging, protected from moisture and direct sunlight to maintain stability.

Orstanorm is taken orally as a tablet. The patient swallows the tablet whole with water, following the dosing instructions provided by the prescriber.

Serious risks include severe hypertension, myocardial ischemia, cerebrovascular events such as stroke, anaphylactic reactions, serotonin syndrome when combined with serotonergic drugs, and severe peripheral vasospasm that can lead to tissue damage.

Orstanorm should be avoided in patients with uncontrolled hypertension, recent myocardial infarction, severe peripheral vascular disease, known hypersensitivity to ergot alkaloids, or those taking contraindicated medications such as other ergot derivatives or potent CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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