Product image of Ortanol 20 Plus (Omeprazole) supplied by GNH India

Ortanol 20 Plus

Active Ingredient:
Omeprazole
Origin:
EU

Ortanol 20 Plus (Omeprazole)

Omeprazole, the active ingredient in Ortalan 20 Plus, is a proton pump inhibitor presented as a 20 mg tablet for oral use. It reduces gastric acid secretion and is used to treat acid‑related disorders such as gastro‑oesophageal reflux disease and peptic ulcer disease in adults.

GNH India supplies Ortalan 20 Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Gmbh

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Indications & Clinical Uses

Omeprazole acts on the gastric proton pump to manage conditions driven by excess stomach acid.

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief and promotes healing of the oesophageal lining.
  • Peptic ulcer disease: supports ulcer healing and reduces risk of recurrence.
  • Zollinger‑Ellison syndrome: controls gastric acid hypersecretion associated with the condition.

How It Works

  • Omeprazole selectively and irreversibly inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid production, it markedly lowers both basal and stimulated gastric acidity, allowing mucosal healing and symptom control.

Side Effects

Adverse reactions to omeprazole are generally mild but can vary in frequency.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: usually self‑limiting.
  • Nausea: occasional upset stomach.
  • Abdominal pain: mild cramping.
  • Flatulence: increased intestinal gas.
  • Constipation: occasional difficulty passing stools.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis risk.
  • Hypomagnesemia: low serum magnesium levels.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Acute interstitial nephritis: kidney inflammation.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Fracture risk: possible reduction in bone mineral density with long‑term use.

Precautions & Warnings

Before initiating omeprazole therapy, consider the following safety measures:

  • Assess renal function: adjust use in severe impairment.
  • Review hepatic status: use with caution in liver disease.
  • Evaluate need for long‑term therapy: weigh benefits against potential bone density loss.
  • Monitor electrolytes: especially magnesium during prolonged treatment.
  • Consider drug‑induced nutrient absorption issues: vitamin B12 and iron may be affected.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Omeprazole can alter the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, may increase cardiovascular risk.
  • Atazanavir: decreased antiviral exposure, compromising HIV therapy.
  • Dasatinib: lowered plasma concentrations, reducing efficacy.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, requiring more frequent monitoring.
  • Phenytoin: may reduce serum levels, risking seizure control.
  • Methotrexate: increased exposure, especially at high doses.
  • Digoxin: modest rise in serum concentration, watch for toxicity.

Frequently Asked Questions

Ortanol 20 Plus contains omeprazole, a proton pump inhibitor that is prescribed to reduce stomach acid in conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease and Zollinger‑Ellison syndrome. By lowering acid production, it helps relieve symptoms and promotes healing of the gastrointestinal lining.

Omeprazole works by irreversibly blocking the H+/K+‑ATPase enzyme, also known as the gastric proton pump, on the surface of stomach parietal cells. This inhibition stops the final step of acid secretion, leading to a sustained decrease in gastric acidity and allowing damaged tissue to heal.

The appropriate dose of Ortanol 20 Plus is determined by the prescribing clinician based on the specific indication, severity of disease and patient factors. Healthcare professionals set the regimen and duration according to current clinical guidelines and individual patient needs.

Omeprazole is classified as pregnancy category B in many regions, indicating no proven risk in animal studies but limited human data. It may be used during pregnancy only if clearly needed. Breastfeeding mothers should consult a healthcare provider, as small amounts can pass into milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Ortanol 20 Plus (omeprazole) belongs to the proton pump inhibitor class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with newer PPIs like esomeprazole, omeprazole offers similar efficacy at a generally lower cost.

Store Ortanol 20 Plus at temperatures below 25 °C in its original packaging. Protect the tablets from moisture, heat and direct sunlight to maintain stability and potency throughout its shelf life.

Ortanol 20 Plus is taken orally, usually as a whole tablet with a glass of water. It is commonly recommended to swallow the tablet before a meal, but patients should follow the specific timing instructions provided by their prescriber.

Serious but uncommon risks include Clostridioides difficile‑associated colitis, severe low‑magnesium levels, acute interstitial nephritis, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should seek medical attention if they experience persistent diarrhea, muscle cramps, rash or unexplained kidney problems.

Individuals with known hypersensitivity to omeprazole or any component of the tablet should avoid it. Caution is also advised for patients with severe liver impairment, those requiring certain antiplatelet drugs like clopidogrel, and anyone for whom long‑term acid suppression is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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