Orudis (Ketoprofen)

Ketoprofen is a NSAID that acts on inflammatory pathways to reduce pain and swelling.

• Rheumatoid arthritis: helps reduce joint pain and swelling.
• Osteoarthritis: improves mobility by decreasing joint inflammation.
• Acute musculoskeletal pain: provides short‑term relief of pain from sprains, strains and back pain.

• Ketoprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. This reduction in prostaglandin production lessens vascular permeability and nociceptor activation, producing anti‑inflammatory and analgesic effects.

Ketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or light‑headedness.
• Skin rash: mild erythema or itching.
• Elevated liver enzymes: mild, transient increase.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Anaphylactic shock: rapid onset of airway swelling and hypotension.
• Hepatotoxicity: marked elevation of liver enzymes or jaundice.

Ketoprofen should be used with caution in patients with certain health conditions and in specific situations.

• Assess renal function: monitor renal parameters especially in the elderly.
• Evaluate cardiovascular risk: use the lowest effective dose for the shortest duration.
• Monitor gastrointestinal health: consider gastro‑protective agents in high‑risk patients.
• Avoid use in late pregnancy: contraindicated in the third trimester.
• Review concomitant medications: assess for additive NSAID effects.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ketoprozin may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal perfusion.
• Diuretics (especially thiazides): potential for reduced efficacy of antihypertensive therapy.
• Lithium: NSAIDs can increase lithium serum levels.