Orudis (Ketoprofen)

Ketoprofen acts as a topical NSAID to relieve inflammation and pain in musculoskeletal conditions.

• Musculoskeletal pain: provides localized analgesic and anti‑inflammatory relief.
• Osteoarthritis: reduces joint inflammation and improves mobility.
• Rheumatoid arthritis: alleviates joint swelling and discomfort.
• Sprains and strains: eases soft‑tissue inflammation and pain.

• Ketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes reversibly, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By lowering prostaglandin levels at the site of application, the drug reduces local inflammatory responses and provides analgesic effects without significant systemic exposure when used topically.

Ketoprofen may cause a range of local and systemic adverse reactions.

Common Side Effects

• Skin irritation: mild redness or discomfort at the application site.
• Burning sensation: transient warmth or stinging after use.
• Itching: pruritus localized to the treated area.
• Dryness: temporary skin dryness where applied.
• Erythema: mild redness without swelling.

Serious or Rare Side Effects

• Allergic reaction: hives, swelling, or difficulty breathing.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Systemic toxicity: gastrointestinal ulceration or bleeding if absorbed excessively.
• Photosensitivity: heightened skin reaction to sunlight.
• Contact dermatitis: persistent rash requiring medical attention.

When using topical ketoprofen, consider the following safety measures.

• Avoid broken skin: do not apply to open wounds or irritated skin.
• Limit area: restrict use to the recommended surface area to prevent systemic absorption.
• Concomitant NSAIDs: avoid using other NSAIDs concurrently to reduce risk of adverse effects.
• Pre‑existing conditions: caution in patients with a history of gastrointestinal ulceration or bleeding.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened risk of ulceration.
• Lithium: enhanced lithium toxicity.
• Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

• Antihypertensives: possible reduction in blood pressure control.
• Diuretics: potential renal function impact.
• SSRIs or SNRIs: modestly increased bleeding risk.
• ACE inhibitors: may affect renal perfusion.
• Diabetic agents: monitor blood glucose as NSAIDs can affect glycemic control.