Product image of Orudis (Ketoprofen) supplied by GNH India

Orudis

Active Ingredient:
Ketoprofen
Origin:
EU

Orudis (Ketoprofen)

Ketoprofen, the active ingredient in Orudis, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It is used to relieve mild to moderate pain, reduce inflammation, and improve mobility in conditions such as arthritis and postoperative discomfort.

GNH India supplies Orudis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Norge As

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Indications & Clinical Uses

Ketoprofen belongs to the NSAID class and is employed to manage inflammatory and painful conditions.

  • Rheumatoid arthritis: reduces joint inflammation and pain, improving function.
  • Osteoarthritis: alleviates joint stiffness and discomfort.
  • Acute musculoskeletal pain: provides rapid pain relief.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Dysmenorrhea: eases menstrual cramps and associated pain.

How It Works

  • Ketoprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at sites of tissue injury, it diminishes vascular permeability, leukocyte infiltration, and nociceptor sensitisation, resulting in analgesic and anti‑inflammatory effects.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset after dosing.
  • Dyspepsia: indigestion or heartburn.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Skin rash: mild erythema or itching.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or reduced kidney function.
  • Hepatic dysfunction or elevated liver enzymes.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic shock: rapid allergic response.
  • Cardiovascular events: increased risk of thrombosis.

Precautions & Warnings

When prescribing ketoprofen, clinicians should consider several safety measures.

  • Gastro‑intestinal risk: assess history of ulcers before use.
  • Renal function: monitor creatinine in patients with kidney disease.
  • Cardiovascular caution: avoid in patients with uncontrolled hypertension or heart failure.
  • Hypersensitivity: do not use in individuals allergic to NSAIDs.
  • Pregnancy: avoid in the third trimester due to fetal risk.
  • Use the lowest effective dose for the shortest duration.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ketoprofen can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.
  • ACE inhibitors or ARBs: possible renal function decline.
  • Lithium: elevated lithium levels, risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce renal perfusion.
  • Methotrexate: decreased clearance, potential toxicity.
  • SSRIs: modest increase in bleeding tendency.
  • Antihypertensives: possible reduction in blood pressure control.
  • Oral hypoglycemics: altered glucose control.

Frequently Asked Questions

Orudis contains ketoprofen, an NSAID indicated for relieving mild to moderate pain and inflammation. It is commonly prescribed for rheumatoid arthritis, osteoarthritis, acute musculoskeletal pain, postoperative discomfort, and dysmenorrhea, helping to reduce swelling, improve joint function, and provide analgesia.

Ketoprofen blocks the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which are essential for producing prostaglandins. By lowering prostaglandin levels at sites of injury, it reduces inflammation, decreases pain‑signal transmission, and lowers fever, resulting in symptomatic relief.

The specific dose of Orudis is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Healthcare providers set the appropriate strength, frequency, and duration according to clinical guidelines and individual needs.

Ketoprofen, like other NSAIDs, is generally avoided in the third trimester of pregnancy because it may affect fetal cardiovascular function. Use during earlier stages or while breastfeeding should be decided by a healthcare professional, weighing potential benefits against risks.

To request Orudis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Ketoprofen offers analgesic and anti‑inflammatory potency comparable to ibuprofen and naproxen, but it may have a slightly higher risk of gastrointestinal irritation. Its relatively short half‑life allows flexible dosing, and it is often chosen when rapid pain control is needed.

Orudis tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light, and ensure the container is tightly closed to maintain product stability.

Orudis is supplied as oral tablets that are taken by mouth with a full glass of water. It can be taken with or without food, although taking it with meals may reduce gastrointestinal discomfort.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should be monitored for signs of bleeding, kidney dysfunction, or allergic reactions, especially if they have pre‑existing risk factors.

Orudis should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, and in the third trimester of pregnancy. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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