Product image of Oslif Breezhaler (Indacaterol) supplied by GNH India

Oslif Breezhaler

Active Ingredient:
Indacaterol
Origin:
EU

Oslif Breezhaler (Indacaterol)

Indacaterol, the active ingredient in Oslif Breezhaler, is a Long‑acting beta2‑adrenergic agonist (LABA) presented as an inhalation powder for inhalation use. It provides bronchodilation for maintenance therapy in chronic obstructive pulmonary disease (COPD) in adult patients.

GNH India supplies Oslif Breezhaler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novartis Europharm Limited

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Indications & Clinical Uses

Indacaterol is a long‑acting bronchodilator used in the management of chronic obstructive pulmonary disease and related conditions.

  • Chronic obstructive pulmonary disease (COPD): maintenance bronchodilation to improve airflow and reduce symptoms.
  • Chronic bronchitis: reduces frequency of exacerbations and improves quality of life.
  • Emphysema: helps sustain lung function and ease breathing.

How It Works

  • Indacaterol selectively binds to beta2‑adrenergic receptors on airway smooth muscle, activating adenylate cyclase and increasing cyclic AMP levels. The rise in cAMP leads to relaxation of bronchial smooth muscle, producing prolonged bronchodilation that improves airway patency and reduces airflow limitation in COPD patients.

Side Effects

Common Side Effects

  • Cough: mild to moderate irritation of the throat.
  • Throat irritation: discomfort or soreness after inhalation.
  • Headache: transient mild headache.
  • Nasopharyngitis: inflammation of the nasal passages and throat.
  • Dizziness: occasional light‑headed sensation.
  • Tremor: fine shaking of hands or limbs.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: sudden worsening of breathing.
  • Hypersensitivity reactions: rash, itching, or swelling.
  • Angioedema: rapid swelling of face, lips, or tongue.
  • Severe chest pain: may indicate cardiac involvement.
  • Arrhythmia: irregular heart rhythm.
  • Anaphylaxis: life‑threatening allergic response.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess lung function: confirm diagnosis and severity of COPD.
  • Monitor symptoms: watch for worsening breathlessness or exacerbations.
  • Avoid in hypersensitivity: do not use if patient has known allergy to indacaterol.
  • Cardiovascular caution: use carefully in patients with arrhythmias or ischemic heart disease.
  • Instruct on technique: ensure proper use of the Breezhaler device.
  • Store at ambient temperature below 25°C: keep in original pack, protect from moisture.

Avoid Interactions

Indacaterol may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect.
  • MAO inhibitors: potential for increased cardiovascular stimulation.
  • Other LABAs: risk of additive bronchospasm.

Moderate Interactions (Monitor Closely)

  • Diuretics: may increase risk of hypokalaemia.
  • Theophylline: may raise plasma concentrations.
  • Corticosteroids: may enhance systemic exposure.
  • Anticholinergics: monitor for additive anticholinergic effects.

Frequently Asked Questions

Oslif Breezhaler contains indacaterol, a long‑acting beta2‑adrenergic agonist indicated for maintenance therapy in chronic obstructive pulmonary disease (COPD). It helps keep the airways open, improves breathing, and reduces the frequency of COPD exacerbations when used regularly as prescribed.

Indacaterol selectively activates beta2‑adrenergic receptors on airway smooth muscle, stimulating adenylate cyclase to raise cyclic AMP levels. The increased cAMP causes relaxation of the bronchial muscles, leading to prolonged bronchodilation that eases airflow obstruction in COPD patients.

The prescribed dose of Oslif Breezhaler is determined by the treating physician based on the patient’s clinical condition and response. The medication is delivered via a Breezhaler inhalation device, and the prescriber specifies the number of inhalations per day.

Safety of indacaterol in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Oslif Breezhaler delivers indacaterol, a once‑daily LABA, offering prolonged bronchodilation with a convenient dosing schedule. Compared with short‑acting bronchodilators, it provides steadier airway support, while other LABAs may require twice‑daily dosing or different inhaler devices.

Store Oslif Breezhaler at ambient temperature below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Do not expose the inhaler to extreme heat or humidity, as this may affect powder integrity and device performance.

The medication is inhaled using the Breezhaler device. The patient removes a capsule, inserts it into the inhaler, and inhales forcefully through the mouthpiece as instructed. Proper technique, including a full exhalation before inhalation and a steady breath hold afterward, ensures optimal drug delivery.

Serious risks include paradoxical bronchospasm, severe hypersensitivity reactions such as angioedema, and cardiovascular events like arrhythmia or chest pain. Patients should seek immediate medical attention if they experience sudden worsening of breathing, swelling of the face or throat, or chest discomfort.

Oslif Breezhaler should be avoided in individuals with known hypersensitivity to indacaterol or any component of the formulation. Caution is advised for patients with significant cardiovascular disease, uncontrolled arrhythmias, or severe hepatic impairment, and it is not recommended for use in children.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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