Product image of Osmohale (Mannitol) supplied by GNH India

Osmohale

Active Ingredient:
Mannitol
Origin:
EU

Osmohale (Mannitol)

Mannitol, the active ingredient in Osmohale, is an osmotic diuretic presented as a sterile powder for intravenous use. It is employed in renal diuresis and osmotherapy, particularly in acute kidney injury and to reduce intracranial pressure in critical care settings.

GNH India supplies Osmohale as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and transplant centres worldwide.

Manufacturer / TM Owner

Pharmaxis Europe Limited

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Indications & Clinical Uses

Osmohale is an osmotic diuretic that acts on renal water handling and intracranial fluid dynamics. It is indicated for:

  • Acute kidney injury: facilitates diuresis to manage fluid overload.
  • Cerebral edema: reduces intracranial pressure by creating an osmotic gradient.
  • Glaucoma surgery: assists in intra‑ocular pressure control during operative procedures.

How It Works

  • Mannitol exerts its effect by increasing plasma osmolarity when administered intravenously. The elevated osmotic pressure draws water from intracellular and interstitial spaces into the vascular compartment, promoting renal excretion of water and electrolytes and decreasing cerebral and ocular fluid volume.

Side Effects

Adverse reactions to mannitol may vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Nausea: occasional upset stomach.
  • Electrolyte imbalance: changes in sodium or potassium levels.
  • Transient hypotension: brief drop in blood pressure.
  • Pulmonary edema: fluid accumulation in the lungs.

Serious or Rare Side Effects

  • Acute renal failure: sudden loss of kidney function.
  • Severe hyponatremia: dangerously low sodium concentration.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Hyperosmolar coma: extreme increase in plasma osmolarity.
  • Intracerebral hemorrhage: bleeding within the brain tissue.

Precautions & Warnings

When using Osmohale, clinicians should consider several safety measures:

  • Renal function monitoring: assess baseline and ongoing kidney performance.
  • Fluid balance assessment: track input‑output records.
  • Electrolyte surveillance: check serum sodium and potassium regularly.
  • Cardiovascular status: observe for hypotension or cardiac stress.
  • Contraindications review: avoid in patients with established severe renal impairment.
  • Store at below 25°C: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mannitol may interact with several concomitant medications.

Major Interactions (Avoid)

  • Loop diuretics: combined use can intensify volume depletion.
  • Nephrotoxic antibiotics: may increase risk of renal injury.
  • Insulin: rapid shifts in plasma osmolarity can alter glucose control.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may potentiate hypotensive effects.
  • Cardiac glycosides: fluid shifts can affect drug plasma levels.
  • Anticoagulants: altered renal clearance may modify anticoagulant activity.

Frequently Asked Questions

Osmohale contains mannitol, an osmotic diuretic used primarily to promote urine output in acute kidney injury, to lower intracranial pressure in cerebral edema, and to assist with intra‑ocular pressure control during glaucoma surgery. It is administered under medical supervision in hospital or clinic settings.

Mannitol increases plasma osmolarity when given intravenously, drawing water from cells and interstitial spaces into the bloodstream. This osmotic shift enhances renal excretion of water and electrolytes and reduces fluid volume in the brain and eye, helping to manage edema and pressure.

The dose of Osmohale is determined by the prescribing clinician based on the patient’s condition, weight, renal function and therapeutic goals. Healthcare professionals calculate the appropriate volume and concentration according to established clinical guidelines.

Mannitol is classified as pregnancy category C in many regions, indicating that risk cannot be ruled out. It should only be used when the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding, so caution is advised and a healthcare provider should be consulted.

To order Osmohale, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mannitol, the active ingredient in Osmohale, is a widely used osmotic diuretic with a rapid onset of action. Compared with hypertonic saline, mannitol provides a predictable osmotic effect and is eliminated unchanged by the kidneys, making it suitable for patients requiring precise fluid management.

Osmohale should be stored at temperatures below 25 °C, in its original sealed container, protected from moisture and direct sunlight. Maintaining these conditions helps preserve sterility and potency until the product is prepared for intravenous use.

Osmohale is administered intravenously by a healthcare professional. The sterile powder is reconstituted with a compatible diluent, typically normal saline, and infused over a period determined by the clinical indication and patient response.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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