Product image of Ospolot (Sultiame) supplied by GNH India

Ospolot

Active Ingredient:
Sultiame
Origin:
EU

Ospolot (Sultiame)

Sultiame, the active ingredient in Ospolot, is a carbonic anhydrase inhibitor presented as an oral tablet for oral use. It treats edema and hypertension in patients who require diuretic therapy.

GNH India supplies Ospolot as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Desitin Arzneimittel Gmbh

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Indications & Clinical Uses

Sultiame acts on renal carbonic anhydrase to promote fluid loss, making Ospolot useful in conditions that benefit from diuresis.

  • Edema: reduces excess fluid accumulation and swelling.
  • Hypertension: lowers elevated blood pressure by increasing urinary sodium and water excretion.

How It Works

  • Sultiame inhibits the enzyme carbonic anhydrase in the proximal renal tubules, decreasing bicarbonate reabsorption. This leads to reduced sodium and water reabsorption, increased urinary output, and a mild metabolic acidosis that together produce a diuretic effect useful for managing fluid overload and blood pressure.

Side Effects

Common side effects are generally mild and related to its diuretic action.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness: especially on standing.
  • Nausea: occasional gastrointestinal upset.
  • Fatigue: feeling of reduced energy.
  • Increased urination: expected diuretic response.
  • Mild electrolyte imbalance: low potassium or sodium.

Serious or Rare Side Effects

  • Severe metabolic acidosis: significant blood pH drop.
  • Kidney stones: due to altered urine composition.
  • Allergic reactions: rash, itching, or swelling.
  • Blood disorders: rare agranulocytosis or leukopenia.
  • Severe dehydration: excessive fluid loss.
  • Hepatic dysfunction: abnormal liver enzymes.

Precautions & Warnings

Patients should be evaluated for factors that could increase risk while using Ospolot.

  • Renal function: monitor in patients with impaired kidneys.
  • Electrolytes: check serum potassium and sodium regularly.
  • Gout: may precipitate gout attacks.
  • Pregnancy: use only if benefit outweighs potential risk.
  • Drug interactions: review all concomitant medicines.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ospolot can affect or be affected by several other medicines.

Major Interactions (Avoid)

  • Loop diuretics: may cause excessive diuresis.
  • Lithium: can increase lithium serum levels.
  • Corticosteroids: may enhance electrolyte loss.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: additive blood pressure lowering.
  • NSAIDs: may reduce diuretic efficacy.

Frequently Asked Questions

Ospolot contains the diuretic Sultiame and is used to manage fluid overload conditions such as edema and to help lower high blood pressure in patients who need a carbonic anhydrase inhibitor.

Sultiame blocks carbonic anhydrase in the kidney’s proximal tubules, reducing bicarbonate reabsorption. This decreases sodium and water reabsorption, leading to increased urine output and a modest reduction in blood pressure.

The specific dose of Ospolot is determined by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. No standard dose is provided here.

Safety data for Sultiame in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

To order Ospolot, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ospolot (Sultiame) is a carbonic anhydrase inhibitor, differing from loop or thiazide diuretics that act on other segments of the nephron. It generally produces a milder diuretic effect and may be chosen when a less aggressive fluid removal is desired or when specific metabolic effects are needed.

Store Ospolot at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and direct sunlight to maintain stability.

Ospolot is taken orally, usually with a glass of water. The exact timing (e.g., with meals or on an empty stomach) should follow the prescribing clinician’s instructions.

Serious risks include severe metabolic acidosis, significant electrolyte disturbances, kidney stone formation, and rare allergic reactions. Patients should be monitored for signs of these conditions, especially during the initial treatment period.

Ospolot should be avoided in patients with known hypersensitivity to Sultiame, severe renal impairment, uncontrolled electrolyte imbalances, or in those for whom the risk of metabolic acidosis outweighs any therapeutic benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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