Otrason Dreifa 60 Skammtar/120 Skammtar (Fluticasone Propionate)

Fluticasone propionate nasal spray is used to manage inflammatory conditions of the nasal passages.

• Allergic rhinitis: reduces nasal congestion, itching and sneezing.
• Seasonal allergic rhinitis: controls symptoms triggered by seasonal allergens.
• Nasal polyps: decreases polyp size and improves nasal airflow.

• Fluticasone propionate acts as an agonist of the glucocorticoid receptor in nasal mucosal cells. Binding activates gene transcription that suppresses inflammatory cytokine production, reduces vascular permeability, and limits edema, providing local anti‑inflammatory effects within the nasal passages.

Adverse reactions to fluticasone nasal spray are generally mild to moderate and reflect local exposure of the nasal mucosa.

Common Side Effects

• Nasal irritation or burning sensation.
• Epistaxis (nosebleeds).
• Headache.
• Throat irritation.
• Cough.
• Unpleasant taste or smell.

Serious or Rare Side Effects

• Nasal septal perforation.
• Severe allergic reaction (anaphylaxis).
• Vision changes such as cataracts or glaucoma.
• Persistent fungal infection of the nasal passages.
• Suppression of the hypothalamic‑pituitary‑adrenal axis with systemic exposure.
• Worsening of nasal polyps after abrupt discontinuation.

When using fluticasone nasal spray, consider the following safety measures:

• Assess for active infections: avoid use if untreated bacterial, fungal or viral nasal infections are present.
• Monitor for systemic effects: prolonged high‑dose use may affect adrenal function.
• Caution in glaucoma patients: monitor intra‑ocular pressure.
• Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
• Pediatric use: follow pediatric dosing guidelines and monitor growth.
• Store at ambient temperature: keep below 25°C, protect from moisture and keep in original packaging.

Fluticasone nasal spray may interact with other medications that affect corticosteroid metabolism or increase systemic exposure.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic fluticasone levels.
• Systemic corticosteroids: additive systemic glucocorticoid effects.

Moderate Interactions (Monitor Closely)

• Antifungal azoles (e.g., fluconazole): may modestly raise flutatec.
• Ritonavir (HIV protease inhibitor): may increase systemic exposure.
• Certain antihistamines: may alter nasal absorption.
• Nasal decongestant sprays: risk of rebound congestion if used together.