Otrivin Menthol Preservative Free (Xylometazoline Hydrochloride)

Xylometazoline nasal spray acts on the nasal mucosa to reduce swelling and improve airflow.

• Common cold: alleviates nasal congestion and improves breathing.
• Sinusitis: reduces mucosal edema, helping sinus drainage.
• Allergic rhinitis: decreases nasal obstruction caused by allergic inflammation.

• Xylometazoline is an alpha‑adrenergic agonist that selectively stimulates alpha‑1 and alpha‑2 receptors in the nasal mucosal blood vessels. This stimulation causes vasoconstriction, leading to reduced blood flow, decreased mucosal edema, and improved nasal airway patency.

Adverse reactions are generally mild and self‑limiting.

Common Side Effects

• Nasal burning or stinging sensation.
• Mild nasal dryness.
• Sneezing.
• Headache.
• Transient taste disturbance.

Serious or Rare Side Effects

• Persistent nasal irritation or ulceration.
• Severe headache or facial pain.
• Hypertension exacerbation.
• Rebound congestion with prolonged use.
• Allergic reaction such as rash or swelling.

Before using Otrivin Menthol Preservative Free, consider the following safety measures:

• Age restriction: Not recommended for children under 6 years without medical advice.
• Duration of use: Limit to 3‑5 days to avoid rebound congestion.
• Pre‑existing conditions: Use caution in patients with hypertension, heart disease, diabetes, thyroid disorders, or glaucoma.
• Concomitant nasal medications: Avoid using other topical decongestants simultaneously.
• Pregnancy and lactation: Consult a healthcare professional before use.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Xylometazoline may interact with certain systemic and topical agents.

Major Interactions (Avoid)

• Mono‑mono‑mono  :  

-   Moderate  :   -  .