Product image of Otrivin Moisturising Formula (Xylometazoline Hydrochloride) supplied by GNH India

Otrivin Moisturising Formula

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Otrivin Moisturising Formula (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Otrivin Moisturising Formula, is an alpha‑adrenergic nasal decongestant presented as a nasal spray for topical intranasal use. It relieves nasal congestion associated with the common cold, sinusitis and allergic rhinitis in adults and children.

GNH India supplies Otrivin Moisturising Formula as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Hellas Single Member Societe Anonyme

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Indications & Clinical Uses

Xylometazoline is a topical nasal decongestant that acts on the adrenergic receptors of the nasal mucosa.

  • Common cold: reduces nasal blockage and improves airflow, helping patients breathe more easily.
  • Allergic rhinitis: alleviates congestion caused by allergic inflammation, decreasing nasal stuffiness.
  • Sinusitis: helps relieve sinus pressure by decongesting nasal passages, supporting drainage and comfort.

How It Works

  • Xylometazoline Hydrochloride stimulates α‑adrenergic receptors on the vascular smooth muscle of the nasal mucosa, causing vasoconstriction. This reduces blood flow to the nasal tissues, leading to decreased mucosal edema and improved airway patency. The localized effect limits systemic absorption, providing rapid relief of nasal congestion without significant systemic adrenergic activity.

Side Effects

Adverse reactions may occur following intranasal administration of xylometazoline.

Common Side Effects

  • Nasal irritation or burning sensation
  • Dryness of the nasal mucosa
  • Sneezing or mild epistaxis
  • Headache
  • Altered taste perception
  • Transient dizziness

Serious or Rare Side Effects

  • Severe hypertension or hypertensive crisis
  • Cardiac arrhythmias
  • Nasal ulceration or perforation with prolonged use
  • Anaphylactic reaction
  • Rebound nasal congestion after extended use

Precautions & Warnings

Use of xylometazoline requires attention to several safety considerations.

  • Limit duration of use: restrict to 3‑5 days to avoid rebound congestion.
  • Caution in hypertension: monitor blood pressure regularly during therapy.
  • Not for children under 2 years: safety and efficacy not established in this age group.
  • Avoid concurrent use with other vasoconstrictive nasal products: may increase systemic exposure.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Xylometazoline may interact with other medications, necessitating careful review.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertension.
  • Beta‑blockers: potential additive vasoconstrictive effect.
  • Other nasal decongestants: increased risk of systemic vasoconstriction.

Moderate Interactions (Monitor Closely):\n- Antihypertensive agents: possible reduction in blood‑pressure‑lowering efficacy.

  • Tricyclic antidepressants: may augment cardiovascular effects.

Frequently Asked Questions

Otrivin Moisturising Formula is an intranasal spray containing xylometazoline hydrochloride. It is used to provide rapid relief of nasal congestion caused by the common cold, sinusitis, and allergic rhinitis by constricting blood vessels in the nasal mucosa.

Xylometazoline acts as an α‑adrenergic agonist. When applied to the nasal lining, it binds to α‑receptors on the vascular smooth muscle, causing vasoconstriction. This reduces swelling of the nasal tissues, opens the airway, and eases breathing.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s age, condition, and response. Typically, a few sprays per nostril are used, but the exact regimen should follow the prescriber’s instructions.

Safety data in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Otrivin’s active ingredient, xylometazoline, is a selective α‑adrenergic agonist offering rapid, localized decongestion with minimal systemic effects. Compared with older agents such as phenylephrine, xylometazoline often provides longer‑lasting relief and a lower incidence of systemic side effects when used as directed.

Store the nasal spray at room temperature, below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain product integrity.

The product is administered as a nasal spray. The user gently inserts the tip into each nostril and presses the pump to deliver the recommended number of sprays, usually while keeping the head upright. No oral ingestion is involved.

Serious risks, though rare, include severe hypertension, cardiac arrhythmias, nasal ulceration or perforation with prolonged use, and anaphylactic reactions. Patients should discontinue use and seek medical attention if they experience any of these severe symptoms.

Individuals with known hypersensitivity to xylometazoline or any formulation component should avoid the product. It is also contraindicated in patients with severe hypertension, coronary artery disease, or those taking monoamine oxidase inhibitors. Children under two years of age should not use it unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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