Product image of Otrivine Adult Menthol (Xylometazoline Hydrochloride) supplied by GNH India

Otrivine Adult Menthol

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Otrivine Adult Menthol (Xylometazoline Hydrochloride)

Xylometazoline hydrochloride, the active ingredient in Otrivine Adult Menthol, is a nasal decongestant presented as a nasal spray for topical intranasal use. It relieves nasal blockage caused by colds, allergic rhinitis and sinusitis in adults.
GNH India supplies Otrivine Adult Menthol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Uk Trading Limited

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Indications & Clinical Uses

Otrivine Adult Menthol, a topical nasal decongestant, is indicated for conditions that cause nasal airway obstruction.

  • Nasal congestion due to common cold: provides rapid reduction of swelling and improves airflow.
  • Allergic rhinitis: alleviates obstruction caused by allergic inflammation.
  • Acute sinusitis: helps clear the nasal passages to facilitate drainage and breathing.

How It Works

  • Xylometazoline hydrochloride is an imidazoline derivative that acts as an agonist at peripheral alpha‑adrenergic receptors in the nasal mucosa. Stimulation of these receptors causes vasoconstriction of the submucosal blood vessels, reducing edema and mucus formation, which leads to decreased nasal resistance and improved breathing.

Side Effects

Adverse reactions may occur with intranasal use of Otrivine Adult Menthol.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Dryness of the nasal mucosa.
  • Sneezing or mild headache.
  • Altered taste or mild throat discomfort.

Serious or Rare Side Effects

  • Rebound nasal congestion (rhinitis medicamentosa) after prolonged use.
  • Severe hypertension or arrhythmia.
  • Nasal ulceration or epistaxis.
  • Anaphylactic reaction or severe hypersensitivity.

Precautions & Warnings

Before using Otrivine Adult Menthol, consider the following precautions.

  • Duration of use: limit to 3‑5 consecutive days to avoid rebound congestion.
  • Hypertension: avoid or use under medical supervision if you have high blood pressure.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Age restriction: not recommended for children under 12 years of age.
  • Concomitant sympathomimetics: avoid using with other nasal decongestants to prevent excessive vasoconstriction.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Xylometazoline may interact with other medicines that affect the cardiovascular or sympathetic systems.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other topical nasal decongestants (e.g., phenylephrine): additive vasoconstriction may cause severe hypertension.
  • Systemic sympathomimetics (e.g., pseudoephedrine): may amplify cardiovascular effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia induced by xylometazoline.
  • Antihypertensive agents: possible reduction in blood‑pressure‑lowering effect.
  • Tricyclic antidepressants: monitor for increased cardiovascular stimulation.

Frequently Asked Questions

Otrivine Adult Menthol is a nasal spray that contains xylometazoline hydrochloride. It is used to temporarily relieve nasal congestion caused by the common cold, allergic rhinitis, or acute sinusitis in adult patients. The product works by narrowing the blood vessels in the nasal passages, which reduces swelling and improves airflow.

Xylometazoline is an alpha‑adrenergic agonist. When applied to the nasal mucosa, it stimulates peripheral alpha‑1 receptors, causing vasoconstriction of the small blood vessels. This reduces mucosal edema and limits fluid exudation, leading to a rapid decrease in nasal obstruction and easier breathing.

The exact dosing regimen for Otrivine Adult Menthol is determined by the prescribing healthcare professional. Typically, adults are instructed to spray a specified number of sprays per nostril, not exceeding the recommended maximum daily frequency, and to limit treatment to a few days to avoid rebound congestion.

Safety data for xylometazoline during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician. The prescriber will weigh potential benefits against any possible risks to the mother and infant before recommending the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.

Both xylometazoline and oxymetazoline belong to the imidazoline class and act as alpha‑adrenergic agonists, providing similar rapid decongestion. Xylometazoline may have a slightly longer duration of action, but both share comparable safety profiles and the same risk of rebound congestion if used beyond the recommended period.

Store the nasal spray at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and store it out of reach of children. Do not freeze the product.

Otrivine Adult Menthol is administered as a topical intranasal spray. The user gently inserts the nozzle into each nostril and delivers the prescribed number of sprays, usually one to two per nostril, while inhaling gently. The spray should be used only as directed by a healthcare professional.

Serious adverse events, although rare, include severe hypertension, arrhythmias, nasal ulceration, epistaxis, and anaphylactic reactions. Prolonged use beyond three to five days can cause rebound nasal congestion (rhinitis medicamentosa). Patients should seek immediate medical attention if they experience chest pain, rapid heartbeat, severe headache, or signs of an allergic reaction.

The product should be avoided by individuals with known hypersensitivity to xylometazoline or any excipients, patients with severe hypertension or cardiovascular disease, children under 12 years of age, and anyone using monoamine oxidase inhibitors or other topical nasal decongestants without medical advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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