Otrivine Junior Sine Conservans Abschwellend (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride acts on the nasal mucosa to reduce swelling and improve airflow.

• Common cold‑related nasal congestion: alleviates blockage and eases breathing in children.
• Acute sinusitis: decreases mucosal edema to support sinus drainage.
• Allergic rhinitis: reduces nasal swelling caused by seasonal allergens.
• Upper respiratory tract infections: provides short‑term decongestion to improve comfort.

• Xylometazoline Hydrochloride is a selective alpha‑adrenergic agonist that stimulates alpha‑1 receptors on the vascular smooth muscle of the nasal mucosa, causing vasoconstriction. This reduces blood flow, limits edema, and opens the nasal passages, thereby relieving congestion.

Xylometazoline Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Nasal irritation or burning sensation
• Dryness of the nasal mucosa
• Sneezing
• Bitter taste after administration
• Mild headache
• Epistaxis (nosebleed)

Serious or Rare Side Effects

• Severe hypertension or hypertensive crisis
• Tachycardia or arrhythmia
• Allergic reaction (rash, itching, swelling)
• Rebound congestion with prolonged use
• Nasal ulceration
• Vision changes (rare).

When using Xylometazoline Hydrochloride, consider the following safety measures.

• Age restriction: not recommended for children under 2 years without medical advice.
• Duration limit: avoid use for more than 3‑5 consecutive days to prevent rebound congestion.
• Cardiovascular conditions: use with caution in patients with hypertension or heart disease.
• Concurrent nasal decongestants: do not combine with other topical decongestants.
• Allergies: discontinue if signs of hypersensitivity appear.
• Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Xylometazoline Hydrochloride can interact with other medications, affecting safety or efficacy.

Major Interactions (Avoid)

• Other topical nasal decongestants (risk of excessive vasoconstriction).
• Monoamine oxidase inhibitors (potential hypertensive response).

Moderate Interactions (Monitor Closely)

• Systemic sympathomimetics (e.g., pseudoephedrine) – may increase cardiovascular effects.
• Antihypertensive agents – possible attenuation of blood‑pressure‑lowering effect.
• Antidepressants that influence norepinephrine levels – monitor blood pressure.