Oversano (Ketorolac Trometamol)

Ketorolac Trometamol is an NSAID that provides analgesic and anti‑inflammatory effects for several acute pain conditions.

• Post‑operative pain: helps achieve effective pain relief after surgery.
• Renal colic: reduces pain associated with kidney stones.
• Musculoskeletal injury: alleviates pain from sprains, strains and contusions.
• Acute migraine (off‑label): may lessen headache intensity when other treatments fail.
• Dental pain: provides short‑term relief following dental procedures.

• Ketorolac trometamol inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By reducing prostaglandin levels, it diminishes peripheral sensitisation and central pain signalling, producing potent analgesic effects comparable to opioid analgesics in the short term.

Ketorolac Trometamol may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Elevated blood pressure.
• Renal function changes: transient increase in serum creatinine.
• Injection site irritation (if administered parenterally).

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe hypersensitivity reactions including anaphylaxis.
• Thrombotic events such as myocardial infarction or stroke.
• Acute kidney injury.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Hepatotoxicity.

Ketorolac Trometamol should be used with caution and under professional supervision.

• Assess renal function: avoid use in patients with severe renal impairment.
• Monitor gastrointestinal risk: use gastro‑protective agents in high‑risk individuals.
• Evaluate cardiovascular status: avoid in patients with recent myocardial infarction.
• Limit duration: restrict use to the shortest possible period, generally not exceeding five days.
• Review concomitant NSAID or anticoagulant therapy: increase bleeding risk.
• Store at ambient temperature: keep in the original packaging, protect from moisture and light.

Ketorolac Trometamol can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.

Moderate Interactions (Monitor Closely)

• ACE inhibitors, ARBs: may reduce renal perfusion and function.
• Diuretics: potential for reduced kidney function.
• Lithium: NSAIDs can raise lithium serum levels.
• Methotrexate: decreased renal clearance may increase toxicity.
• Corticactives (e.g., prednisone): heightened risk of ulceration.