Product image of Ovestin (Estriol) supplied by GNH India

Ovestin

Active Ingredient:
Estriol
Origin:
EU

Ovestin (Estriol)

Estriol, the active ingredient in Ovestin, is a naturally occurring estrogen presented as a hormone therapy for menopausal symptom relief in women. It is used primarily for estrogen‑deficiency related conditions.

GNH India supplies Ovestin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ovestin contains estradiol and acts on estrogen‑dependent pathways to manage several hormone‑related conditions.

  • Menopausal vasomotor symptoms: Reduces hot flashes and night sweats.
  • Vaginal atrophy: Improves tissue elasticity and lubrication.
  • Osteopenia prevention: Helps maintain bone mineral density in post‑menopausal women.

How It Works

  • Estriol binds to estrogen receptors (ER α and ER β) in target tissues, producing a weaker estrogenic response compared with estradiol. This selective activation modulates gene transcription involved in vascular tone, mucosal integrity and bone remodeling, thereby alleviating symptoms of estrogen deficiency.

Side Effects

Adverse reactions to estradiol are reported across a range of severities.

Common Side Effects

  • Nausea: Mild to moderate gastrointestinal upset.
  • Breast tenderness: Localized discomfort or swelling.
  • Headache: Transient tension‑type headaches.
  • Fluid retention: Mild peripheral edema.
  • Mood changes: Irritability or mild depressive symptoms.

Serious or Rare Side Effects

  • Thromboembolic events: Deep vein thrombosis or pulmonary embolism.
  • Endometrial hyperplasia: Abnormal uterine lining growth.
  • Liver dysfunction: Elevated transaminases.
  • Hormone‑dependent cancer risk: Potential stimulation of breast or ovarian tumors.

Precautions & Warnings

When prescribing estradiol, clinicians should consider several safety aspects.

  • Contraindications: History of estrogen‑dependent neoplasia.
  • Cardiovascular risk: Assess for thromboembolic or stroke history.
  • Liver function: Monitor hepatic enzymes in patients with liver disease.
  • Bone health: Evaluate baseline bone mineral density.
  • Interactions: Review concomitant medications that affect coagulation.
  • Store at below 25°C: Keep in original container, protect from moisture and light.

Avoid Interactions

Estradiol may interact with a variety of medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Combined oral contraceptives: Increases risk of thromboembolism.
  • Anticoagulants (warfarin): Potentiates anticoagulant effect, raising bleeding risk.
  • Hepatotoxic drugs: Heightened liver toxicity potential.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: May reduce blood pressure‑lowering effect.
  • Antidepressants (SSRIs): Can affect estradiol metabolism.
  • Thyroid hormones: May require dose adjustment of levothyroxine.

Frequently Asked Questions

Ovestin contains estriol, a weak estrogen used to treat menopausal symptoms such as hot flashes, vaginal atrophy, and to help maintain bone density in post‑menopausal women. It is prescribed when estrogen replacement is indicated.

Estriol binds to estrogen receptors α and β, producing a milder estrogenic response than estradiol. This selective activation influences gene expression that regulates vascular tone, mucosal health, and bone remodeling, thereby alleviating estrogen‑deficiency symptoms.

The specific dose of Ovestin is determined by the prescribing clinician based on the patient’s condition, age, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

Estriol is a form of estrogen and is generally contraindicated during pregnancy because it may affect fetal development. Breastfeeding mothers should consult their healthcare provider, as estrogen therapy can alter milk production and composition.

To order Ovestin, submit an enquiry on the product page at gnhindia.com, providing the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then replies with pricing, availability, shipping details and necessary import documentation.

Ovestin’s estriol is a weaker estrogen compared with estradiol‑based products, offering a lower risk of estrogen‑related side effects such as endometrial proliferation. It may be preferred for patients needing milder estrogenic activity or those with specific safety concerns.

Store Ovestin at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Maintaining these conditions helps preserve the product’s potency and stability.

Ovestin is supplied as an oral tablet (or other form as specified by the product) and is taken by mouth as directed by the prescriber. The exact administration schedule depends on the individual treatment plan.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, endometrial hyperplasia, and a potential increase in hormone‑dependent cancer risk. Patients should be monitored regularly for these complications.

Ovestin is contraindicated in individuals with a history of estrogen‑dependent cancers, active thromboembolic disease, uncontrolled hypertension, liver dysfunction, or known hypersensitivity to estriol or any formulation excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Estriol

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT