Ovranette (Ethinylestradiol, Levonorgestrel)

Ovranette is a combined hormonal contraceptive that acts on the reproductive endocrine pathway to prevent pregnancy.

• Contraception: Provides reliable prevention of pregnancy when taken as directed.
• Menstrual cycle regulation: Helps achieve more predictable menstrual bleeding patterns.
• Acne management: Reduces androgen‑driven acne in women using it for contraception.

• Ovranette combines ethinylestradiol, a synthetic estrogen, with levonorgestrel, a synthetic progestogen. The estrogen component stabilises the endometrial lining while the progestogen suppresses ovulation by inhibiting the mid‑cycle luteinising hormone surge and thickens cervical mucus, creating a combined effect that prevents fertilisation.

Side effects vary among users and may range from mild to severe.

Common Side Effects

• Nausea: Mild stomach upset, often transient.
• Headache: Tension‑type or migraine‑like pain.
• Breast tenderness: Temporary swelling or sensitivity.
• Spotting between periods: Light bleeding or spotting.
• Weight fluctuation: Minor changes in body weight.
• Mood changes: Irritability or mild mood swings.

Serious or Rare Side Effects

• Deep vein thrombosis: Blood clot formation in veins.
• Pulmonary embolism: Clot that travels to lungs.
• Stroke: Disruption of blood flow to the brain.
• Hepatic adenoma: Benign liver tumour.
• Severe allergic reaction: Hives, swelling, or breathing difficulty.

When using Ovranette, consider the following precautions to ensure safe and effective use.

• Smoking: Avoid smoking, especially if over 35 years old, due to increased clot risk.
• Cardiovascular history: Inform your healthcare provider of any heart disease, hypertension, or stroke history.
• Liver function: Use with caution if you have liver disease or impaired function.
• Medication review: Discuss all current medicines with your prescriber to avoid interactions.
• Pregnancy testing: Perform a pregnancy test before starting and if a period is missed.
• Store at ambient temperature: Keep tablets below 25°C in the original packaging, protected from moisture.

Ovranette may interact with several medicines, altering its effectiveness or increasing adverse event risk.

Major Interactions (Avoid)

• Antiepileptic drugs: Carbamazepine, phenytoin, and phenobarbital can reduce contraceptive efficacy.
• Rifampicin: This antibiotic antibiotic  
• Antibiotics: Antibiotics such  

Moderate   -   -   -