Product image of Oxaliplatin Kalceks (Oxaliplatin) supplied by GNH India

Oxaliplatin Kalceks

Active Ingredient:
Oxaliplatin
Origin:
EU

Oxaliplatin Kalceks (Oxaliplatin)

Oxaliplatin, the active ingredient in Oxaliplatin Kalceks, is a platinum‑based chemotherapy agent presented as a sterile injectable solution for intravenous use. It is employed in the treatment of certain solid tumours, most notably colorectal cancer, and is administered under the supervision of oncology specialists.

GNH India supplies Oxaliplatin Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Oxaliplatin Kalceks is a platinum‑based chemotherapeutic that acts on the DNA replication pathway of malignant cells.

  • Colorectal cancer: used in combination regimens to inhibit tumour growth and improve survival.
  • Gastric cancer: incorporated into multi‑drug protocols to enhance response rates.
  • Pancreatic cancer: added to standard chemotherapy backbones to increase tumour control.

How It Works

  • Oxaliplatin forms reactive platinum complexes that bind to DNA, creating intra‑ and interstrand cross‑links that disrupt DNA replication and transcription. This damage triggers cell‑cycle arrest and apoptosis, preferentially affecting rapidly dividing cancer cells while sparing most normal tissues.

Side Effects

Adverse reactions to Oxaliplatin Kalceks vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting: mild to moderate gastrointestinal upset.
  • Peripheral neuropathy: tingling or numbness, often dose‑related.
  • Fatigue: generalized tiredness during treatment cycles.
  • Diarrhoea: loose stools that may require supportive care.
  • Myelosuppression: reduced blood cell counts, increasing infection risk.
  • Elevated liver enzymes: transient changes in hepatic function tests.

Serious or Rare Side Effects

  • Severe hypersensitivity reactions: anaphylaxis or bronchospasm.
  • Acute neurotoxicity: sudden onset of muscle cramps or difficulty breathing.
  • Persistent neuropathy: long‑lasting sensory deficits after treatment.
  • Cardiotoxicity: rare arrhythmias or myocardial injury.
  • Renal impairment: acute kidney injury in susceptible patients.

Precautions & Warnings

When handling Oxaliplatin Kalceks, clinicians should observe several safety measures.

  • Renal function: assess baseline creatinine and monitor during therapy.
  • Hepatic function: evaluate liver enzymes before each cycle.
  • Neuropathy risk: monitor for sensory changes and adjust dose if needed.
  • Hematologic status: check complete blood counts regularly.
  • Pregnancy and lactation: avoid use unless benefits clearly outweigh risks.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Oxaliplatin Kalceks may interact with other agents, requiring careful management.

Major Interactions (Avoid)

  • Nephrotoxic drugs: concurrent use can exacerbate kidney injury.
  • Highly emetogenic chemotherapy: may increase nausea severity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: may enhance bleeding risk.
  • CYP450 inducers or inhibitors: can alter plasma levels of co‑administered drugs.
  • Radiotherapy: combined use may increase tissue toxicity.
  • Immunosuppressants: heightened infection susceptibility.
  • Electrolyte‑altering agents: monitor potassium and magnesium levels.

Frequently Asked Questions

Oxaliplatin Kalceks is a platinum‑based chemotherapy indicated for the treatment of colorectal, gastric and pancreatic cancers, typically as part of combination regimens prescribed by oncologists.

Oxaliplatin creates platinum‑DNA adducts that cause cross‑linking of DNA strands, disrupting replication and transcription. This triggers cell‑cycle arrest and apoptosis, preferentially targeting rapidly dividing tumour cells.

The dosage of Oxaliplatin Kalceks is individualized by the treating physician based on cancer type, treatment protocol, patient weight, renal function and other clinical factors.

Oxaliplatin is classified as contraindicated in pregnancy and is not recommended while breastfeeding because it can cross the placenta and be excreted in milk, potentially harming the fetus or infant.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Oxaliplatin differs from cisplatin and carboplatin by having a diaminocyclohexane carrier ligand, which reduces nephrotoxicity and ototoxicity but increases the risk of peripheral neuropathy. It is often preferred for colorectal cancer regimens.

Oxaliplatin Kalceks should be stored at ambient temperature, protected from light and moisture, and kept in its original packaging. Reconstituted solutions must be used promptly according to the manufacturer’s instructions.

The product is supplied as a sterile injectable solution for intravenous infusion. Administration is performed by qualified healthcare professionals, usually over 2 hours, with appropriate pre‑hydration and anti‑emetic prophylaxis.

Serious risks include severe hypersensitivity reactions, acute neurotoxicity, persistent peripheral neuropathy, and significant myelosuppression, all of which require immediate medical attention and may necessitate treatment modification.

Patients with known hypersensitivity to oxaliplatin or other platinum compounds, severe pre‑existing neuropathy, uncontrolled renal or hepatic impairment, and pregnant or breastfeeding women should not be treated with Oxaliplatin Kalceks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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