Product image of Oxaliplatin Teva (Oxaliplatin) supplied by GNH India

Oxaliplatin Teva

Active Ingredient:
Oxaliplatin
Origin:
EU

Oxaliplatin Teva (Oxaliplatin)

Oxaliplatin, the active ingredient in Oxaliplatin Teva, is a platinum‑based chemotherapy agent presented as a sterile solution for intravenous infusion use. It is employed in the treatment of certain solid tumours, most notably colorectal cancer, and is administered under the supervision of oncologists.

GNH India supplies Oxaliplatin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Oxaliplatin Teva is a platinum‑based chemotherapeutic that interferes with DNA replication in malignant cells.

  • Colorectal cancer: enhances survival when combined with fluoropyrimidine‑based regimens.
  • Gastric cancer: used as part of combination therapy for advanced disease.
  • Pancreatic cancer: contributes to tumour response in multi‑drug protocols.

How It Works

  • Oxaliplatin forms reactive platinum complexes that covalently bind to DNA bases, creating intra‑ and interstrand cross‑links that impede DNA replication and transcription. This DNA damage triggers apoptosis in rapidly dividing cancer cells while sparing most normal tissues.

Side Effects

Adverse reactions to Oxaliplatin Teva are observed across a range of severity.

Common Side Effects

  • Peripheral neuropathy: tingling or numbness, often dose‑related.
  • Nausea and vomiting: may require anti‑emetic prophylaxis.
  • Diarrhoea: typically mild to moderate.
  • Fatigue: generalized tiredness during treatment cycles.
  • Thrombocytopenia: reduced platelet count observed in blood tests.
  • Elevated liver enzymes: mild transaminase rise.

Serious or Rare Side Effects

  • Severe peripheral neuropathy: persistent sensory loss.
  • Acute hypersensitivity reactions: flushing, dyspnoea, hypotension.
  • Hemolytic‑type anemia: sudden drop in haemoglobin.
  • Cardiac arrhythmias: irregular heart rhythm episodes.
  • Renal impairment: worsening kidney function.
  • Cytopenias affecting multiple lineages: pancytopenia.

Precautions & Warnings

When handling Oxaliplatin Teva, clinicians should observe specific safety measures.

  • Renal function monitoring: assess creatinine clearance before each cycle.
  • Hepatic function assessment: check liver enzymes regularly.
  • Neuropathy assessment: evaluate sensory changes at each visit.
  • Premedication with anti‑emetics: reduce nausea and vomiting risk.
  • Avoid concurrent neurotoxic agents: limit additive neuropathy risk.
  • Store at below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Oxaliplatin may interact with several concomitant medicines.

Major Interactions (Avoid)

  • Aminoglycoside antibiotics: increase risk of nephrotoxicity.
  • High‑dose vitamin C: may reduce platinum‑drug efficacy.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other neurotoxic chemotherapies: additive peripheral neuropathy.
  • CYP‑mediated drugs: potential pharmacokinetic alterations.
  • Loop diuretics: may affect renal clearance of the drug.

Frequently Asked Questions

Oxaliplatin Teva is an injectable platinum‑based chemotherapy indicated for the treatment of advanced colorectal cancer and is also used in combination regimens for gastric and pancreatic cancers. It is administered by a qualified health‑care professional as part of a multi‑drug protocol.

Oxaliplatin creates platinum‑DNA adducts that cause intra‑ and interstrand cross‑links, blocking DNA replication and transcription. This DNA damage triggers programmed cell death (apoptosis) in rapidly dividing tumour cells, limiting tumour growth.

The prescribed dose of Oxaliplatin Teva is determined by the treating oncologist based on the patient’s body surface area, cancer type, and treatment protocol. Exact dosing regimens are individualized and should follow the relevant clinical guidelines.

Oxaliplatin is classified as contraindicated in pregnancy because it may cause fetal harm. It is also not recommended while breastfeeding, as it can be excreted in milk and affect the infant. Women of child‑bearing potential should use effective contraception during treatment.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Oxaliplatin differs from cisplatin and carboplatin in its side‑effect profile, showing less nephrotoxicity and ototoxicity but a higher incidence of peripheral neuropathy. Its efficacy in colorectal cancer is superior, making it the preferred platinum agent in many modern regimens.

Oxaliplatin Teva should be stored below 25 °C in its original packaging, protected from light and moisture. The solution must be prepared in a sterile environment and used promptly after reconstitution according to the product’s stability guidelines.

Oxaliplatin Teva is given as an intravenous infusion, typically over 2 hours, under the supervision of an oncology specialist. Infusion rates and pre‑hydration protocols are adjusted according to the patient’s renal function and overall health status.

Serious risks include severe peripheral neuropathy that may become permanent, acute hypersensitivity reactions, and significant bone‑marrow suppression leading to pancytopenia. Prompt monitoring and supportive care are essential to manage these potential complications.

Patients with known hypersensitivity to oxaliplatin or other platinum compounds, severe pre‑existing neuropathy, uncontrolled renal or hepatic impairment, and pregnant or breastfeeding women should not receive this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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