Oxcarbazepine Sandoz (Oxcarbazepine)

Oxcarbazepine is indicated for seizure disorders that involve the central nervous system.

• Partial seizures: Reduces the frequency and severity of focal onset seizures.
• Generalized tonic‑clonic seizures: Helps control convulsive episodes in patients with this seizure type.
• Mixed seizure types: Provides adjunctive therapy for patients experiencing both focal and generalized seizures.

• Oxcarbazepine is metabolized to its active moiety, licorice‑like monohydroxy derivative, which blocks voltage‑gated sodium channels in neuronal membranes. This inhibition stabilises hyper‑excitable neuronal membranes and reduces repetitive neuronal firing, thereby decreasing seizure activity in the brain.

Oxcarbazepine may cause a range of adverse reactions, most of which are mild to moderate in intensity.

Common Side Effects

• Dizziness
• Drowsiness
• Headache
• Nausea
• Fatigue
• Hyponatremia

Serious or Rare Side Effects

• Severe skin reactions such as Stevens‑Johnson syndrome
• Blood dyscrasias including agranulocytosis
• Hepatic failure
• Life‑threatening hyponatremia
• Suicidal thoughts or behaviors
• Anaphylaxis

When prescribing Oxcarbazepine, clinicians should consider several safety aspects.

• Renal impairment: Adjust dose in patients with reduced kidney function.
• Hepatic impairment: Use caution and monitor liver enzymes.
• Hyponatremia risk: Monitor serum sodium regularly, especially in the elderly.
• Concomitant antiepileptic drugs: Assess for additive CNS depression.
• Pregnancy: Discuss potential risks and benefits with the patient.
• Store at below 25°C: keep in the original packaging, protect from moisture.

• Oxcarbazetone "."  
• Major 
• t 
• g 
• t 
• t.
• """""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""