Oxicodona + Naloxona Sandoz (Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate)

Oxicodona + Naloxona Sandoz is an opioid analgesic used in the management of pain through its action on the central nervous system.

• Moderate to severe acute pain: Provides effective relief when non‑opioid analgesics are inadequate.
• Chronic cancer‑related pain: Helps control persistent pain associated with malignant disease.
• Post‑operative pain: Reduces pain intensity following surgical procedures.
• Severe musculoskeletal pain: Alleviates intense pain from conditions such as severe arthritis or back injury.
• Pain in opioid‑tolerant patients: Offers analgesia while reducing risk of opioid‑induced constipation.
• Break‑through pain episodes: Allows rapid relief of sudden pain spikes.

• Oxicodona + Naloxona combines an opioid agonist (oxycodone) with an opioid antagonist (naloxone). Oxycodone binds to mu‑opioid receptors in the central nervous system, producing analgesia and sedation. Naloxone, poorly absorbed when taken orally, blocks peripheral mu‑receptors, limiting opioid‑induced constipation and reducing abuse potential by antagonising the drug if injected.

Side effects vary depending on individual response and dosage.

Common Side Effects

• Nausea and vomiting: Stomach upset and the urge to vomit.
• Constipation: Reduced bowel movements, a frequent issue with opioids.
• Dizziness or light‑headed dizziness: Feeling faint or unsteady.
• Drowsiness or sedation: Increased sleepiness.
• Dry mouth: Reduced saliva production.
• Itching or rash: Mild skin irritation.

Serious or Rare Side Effects

• Respiratory depression: Slowed or shallow breathing that can be life‑threatening.
• Severe hypotension: Markedly low blood pressure.
• Allergic reactions: Hives, swelling, or anaphylaxis.
• Seizures: Uncontrolled convulsions.
• Hepatic impairment: Liver function disturbances.
• Opioid use disorder : Development of depend or addiction.

• When using Oxicodone + Naloxona Sandoz, several  
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