Oxis Turbuhaler (Formoterol Fumarate Dihydrate)

Formoterol fumarate is a bronchodilator that acts on the airway smooth‑muscle pathway to improve airflow.

• Asthma: improves lung function and reduces symptoms when used regularly as maintenance therapy.
• Chronic obstructive pulmonary disease (COPD): provides sustained bronchodilation to ease breathing and reduce exacerbations.
• Exercise‑induced bronchoconstriction: helps prevent airway narrowing during physical activity when combined with a rapid‑onset reliever.

• Formoterol fumarate dihydrate binds selectively to β2‑adrenergic receptors on airway smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cyclic AMP. The rise in cAMP leads to relaxation of bronchial smooth muscle, producing a prolonged bronchodilatory effect that lasts up to 12 hours, supporting maintenance therapy for obstructive lung diseases.

Formoterol fumarate may cause adverse reactions, most of which are mild to moderate in intensity.

Common Side Effects

• Tremor: mild shaking of the hands.
• Headache: occasional mild to moderate headache.
• Throat irritation: dry or sore throat after inhalation.
• Cough: transient coughing following dose administration.
• Palpitations: sensation of rapid or irregular heartbeat.

Serious or Rare Side Effects

• Paradoxical bronchospasm: worsening airway narrowing after inhalation.
• Cardiovascular events: arrhythmia, tachycardia, or angina in susceptible individuals.
• Hypokalemia: low blood potassium levels, potentially causing muscle weakness.
• Allergic reactions: rash, itching, swelling, or anaphylaxis.
• Hyperglycaemia: elevated blood glucose, particularly in diabetic patients.

When prescribing Oxis Turbuhaler, clinicians should consider patient‑specific factors and follow standard safety measures.

• Assess asthma or COPD severity: confirm that maintenance therapy with a LABA is appropriate.
• Review cardiovascular history: evaluate risk of tachycardia or arrhythmias.
• Monitor for paradoxical bronchospasm: advise patients to seek immediate care if breathing worsens after use.
• Use with inhaled corticosteroid: LABA therapy should be combined with an anti‑inflammatory controller.
• Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

• The safety profile ​         …  
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