Product image of Oxitril (Duloxetine Hydrochloride) supplied by GNH India

Oxitril

Active Ingredient:
Duloxetine Hydrochloride
Origin:
EU

Oxitril (Duloxetine Hydrochloride)

Duloxetine, the active ingredient in Oxitril, is a serotonin‑norepinephrine reuptake inhibitor (SNRI) presented as a tablet for oral use. It is indicated for the treatment of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain in adults. GNH India supplies Oxitril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Oxitril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Adamed Laboratorios S.L.U.

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Indications & Clinical Uses

Duloxetine acts on central nervous system pathways that regulate mood and pain perception.

  • Major depressive disorder: alleviates depressive symptoms and improves functional outcomes.
  • Generalized anxiety disorder: reduces anxiety severity and associated physical symptoms.
  • Diabetic peripheral neuropathic pain: lessens pain intensity and improves quality of life.
  • Fibromyalgia: decreases widespread musculoskeletal pain and fatigue.
  • Chronic musculoskeletal pain: provides relief from chronic low back and osteoarthritis pain.

How It Works

  • Duloxetine inhibits the reuptake of serotonin and norepinephrine by blocking the respective transporters (SERT and NET) in neuronal synapses, increasing the availability of these neurotransmitters in the central nervous system. This dual‑action enhances descending inhibitory pain pathways and modulates mood-regulating circuits, contributing to its antidepressant and analgesic effects.

Side Effects

Duloxetine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea
  • Dry mouth
  • Somnolence
  • Constipation
  • Increased sweating
  • Dizziness

Serious or Rare Side Effects

  • Hepatotoxicity
  • Hypertensive crisis
  • Serotonin syndrome
  • Severe skin reactions (Stevens‑Johnson syndrome)
  • Suicidal thoughts or behaviors
  • Angle‑grating  

Precautions & Warnings

  • When using Dul…

Frequently Asked Questions

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GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

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