Oxomemazine Sans Sucre, Édulcorée À L’acésulfame Potassique Laboratoire Unither (Oxomemazine)

Oxomemazine is a first‑generation antihistamine that acts on histamine‑mediated allergic pathways.

• Allergic rhinitis: reduces nasal congestion, sneezing and itching.
• Urticaria (hives): alleviates skin itching and wheal formation.
• Pruritus associated with minor skin irritations: provides symptomatic relief of itching.
• Motion‑sickness prophylaxis: helps prevent nausea and vomiting related to travel.
• Sedation for short‑term procedural anxiety: offers calming effect before minor procedures.

• Oxomemazine blocks histamine H1 receptors in peripheral tissues and the central nervous system, preventing histamine‑induced vasodilation, increased vascular permeability, and sensory nerve stimulation. By antagonising these receptors, it reduces the classic signs of allergic reactions and also exerts a sedative effect through central H1 blockade.

Oxomemazine may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

• Drowsiness: mild to moderate sleepiness.
• Dry mouth: reduced salivary flow.
• Dizziness: sensation of light‑headedness.
• Blurred vision: temporary visual accommodation changes.
• Constipation: slowed gastrointestinal motility.
• Nausea: mild stomach upset.

Serious or Rare Side Effects

• Cardiac arrhythmias: irregular heart rhythm, especially in patients with pre‑existing heart disease.
• Severe allergic reaction: rash, swelling, or anaphylaxis.
• Extrapyramidal symptoms: involuntary muscle movements or tremor.
• Hepatotoxicity: elevated liver enzymes indicating liver stress.
• Hematologic abnormalities: low white blood cell or platelet counts.
• Neuroleptic malignant syndrome: rare but life‑threatening hyperthermic reaction.

When prescribing Oxomemazine, clinicians should consider several safety aspects.

• Pregnancy: avoid unless clearly needed, as safety data are limited.
• Breastfeeding: use with caution; drug may pass into milk.
• Elderly patients: start with lower dose due to increased sensitivity to sedation.
• Concomitant CNS depressants: monitor for additive drowsiness.
• Driving or operating machinery: advise patients of possible impairment.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Oxomemazine can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of severe hypotension and sedation.
• Other antihistamines: excessive sedation and anticholinergic load.
• CNS depressants (benzodiazepines, opioids): heightened central nervous system depression.

Moderate Interactions (Monitor Closely)

• Alcohol: may increase drowsiness.
• Anticholinergic agents: additive dry‑mouth and constipation effects.
• Cardiac glycosides: potential for altered heart rhythm.
• CYP450 inhibitors: may raise oxomemazine plasma levels.
• CYP450 inducers: may reduce therapeutic effect.