Oxomemazine Sans Sucre, Édulcorée À L’acésulfame Potassique Unither (Oxomemazine)

Oxomemazine is a first‑generation antihistamine that acts on histamine‑mediated pathways to reduce allergic symptoms.

• Allergic rhinitis: helps relieve nasal congestion, itching and sneezing.
• Acute urticaria: reduces the formation of hives and associated itching.
• Cough associated with upper respiratory tract infections: diminishes cough frequency and severity.

• Oxomemazine blocks H1 histamine receptors in peripheral tissues and the central nervous system, preventing histamine‑induced vasodilation, increased vascular permeability, and sensory nerve activation. This antagonism reduces the classic signs of allergy such as itching, swelling, and bronchoconstriction, and also exerts a mild sedative effect through central H1 blockade.

Oxomemazine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Drowsiness: a feeling of sleepiness or reduced alertness.
• Dry mouth: reduced salivation leading to a dry oral cavity.
• Dizziness: light‑headed sensation, especially when standing quickly.
• Gastrointestinal discomfort: nausea or mild stomach upset.
• Blurred vision: temporary visual disturbances.

Serious or Rare Side Effects

• Cardiac arrhythmias: irregular heart rhythm requiring medical attention.
• Severe allergic reactions: rash, swelling, or difficulty breathing.
• Extrapyramidal symptoms: involuntary muscle movements or tremor.
• Hepatotoxicity: signs of liver injury such as jaundice.

Before prescribing Oxomemazine, clinicians should consider several safety aspects.

• Pregnancy: avoid use unless the benefit outweighs the risk.
• Breastfeeding: monitor infant for sedation; consider alternatives.
• Elderly patients: start with lower doses due to increased sensitivity to sedation.
• Concomitant CNS depressants: may enhance drowsiness and impair coordination.
• Driving or operating machinery: advise patients to avoid until they know how the drug affects them.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Oxomemazine can interact with other medications, altering efficacy or safety.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
• Other antihistamines: additive sedation and anticholinergic effects.
• CNS depressants (e.g., benzodiazepines, opioids): heightened central nervous system depression.

Moderate Interactions (Monitor Closely)

• Alcohol: may increase drowsiness.
• Anticholinergic drugs: potential for excessive dry mouth and urinary retention.
• Cardiac glycosides: possible alteration of heart rhythm.