Product image of Oxomemazine Sans Sucre Cristers (Oxomemazine) supplied by GNH India

Oxomemazine Sans Sucre Cristers

Active Ingredient:
Oxomemazine
Origin:
EU

Oxomemazine Sans Sucre Cristers (Oxomemazine)

Oxomemazine, the active ingredient in Oxomemazine Sans Sucre Cristers, is a first‑generation antihistamine presented as a tablet for oral use. It is employed to relieve allergic symptoms such as itching, rash and runny nose in children and adults.
GNH India supplies Oxomemazine Sans Sucre Cristers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cristers

1
Pack/s
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Indications & Clinical Uses

Oxomemazine is a first‑generation antihistamine that acts on histamine‑H1 receptors to alleviate allergic conditions.

  • Allergic rhinitis: reduces sneezing, nasal congestion and itching.
  • Urticaria (hives): diminishes wheal formation and pruritus.
  • Pruritus of the skin: provides relief from generalized itching associated with allergic reactions.

How It Works

  • Oxomemazine blocks histamine H1 receptors in peripheral tissues and the central nervous system, preventing histamine‑mediated vasodilation, increased vascular permeability, and sensory nerve activation. This antagonism reduces the classic signs of allergic inflammation and produces a mild sedative effect due to central H1 blockade.

Side Effects

Oxomemazine may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dry mouth: reduced salivation leading to a sticky sensation.
  • Dizziness: light‑headed feeling, especially when standing quickly.
  • Blurred vision: temporary difficulty focusing.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Cardiac arrhythmias: irregular heart rhythm that may require medical attention.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Hepatotoxicity: signs of liver injury such as jaundice.
  • Extrapyramidal symptoms: involuntary muscle movements or tremor.
  • Hematologic abnormalities: unexplained bruising or low blood counts.

Precautions & Warnings

When prescribing Oxomemazine, clinicians should consider several safety aspects.

  • Pregnancy: avoid use unless the benefit outweighs the risk; limited data are available.
  • Breastfeeding: may pass into milk; weigh benefits against potential infant effects.
  • Elderly patients: start with lower doses due to increased sensitivity to sedation.
  • Concomitant CNS depressants: may enhance drowsiness and impair coordination.
  • Driving or operating machinery: advise patients to assess tolerance before engaging in such activities.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Oxomemazine can interact with other medicines, altering its efficacy or safety profile. Major Interactions (Avoid):\n- Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis and excessive sedation.

  • Other antihistamines: additive sedation and anticholinergic effects.
  • CNS depressants (e.g., benzodiazepines, opioids): heightened drowsiness and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Alcohol: may increase sedation and impair judgment.
  • Anticholinergic drugs: enhanced dry‑mouth and constipation.
  • CYP450 inhibitors (e.g., erythromycin): possible increase in oxox‑​​  
  • CYP   

Frequently Asked Questions

Oxomemazine Sans Sucre Cristers is a first‑generation antihistamine indicated for the symptomatic relief of allergic conditions such as allergic rhinitis, urticaria (hives) and generalised skin pruritus. It works by blocking histamine H1 receptors, thereby reducing itching, sneezing, nasal congestion and rash associated with allergic reactions.

Oxomemazine exerts its effect by competitively antagonising histamine H1 receptors in peripheral tissues and the central nervous system. This blockade prevents histamine‑induced vasodilation, increased vascular permeability and sensory nerve activation, which are responsible for the classic signs of allergy. The central H1 antagonism also produces a mild sedative effect.

The appropriate dose of oxomemazine is determined by the prescribing clinician based on the patient’s age, weight, severity of symptoms and overall health status. Dosage recommendations are provided in the product’s prescribing information and should be followed exactly as directed by a qualified healthcare professional.

Oxomemazine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus, as safety data are limited. During breastfeeding, the drug may be excreted in milk; therefore, a risk‑benefit assessment is required, and alternative treatments may be considered when possible.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Oxomemazine belongs to the first‑generation antihistamine class, which generally provides effective symptom relief but is associated with higher sedation and anticholinergic effects compared with second‑generation agents such as cetirizine or loratadine. Choice of therapy depends on clinical needs, patient tolerance for sedation and the risk‑benefit profile for each individual.

Oxomemazine tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Ensure the container is tightly closed to maintain product stability throughout its shelf life.

Oxomemazine is administered orally, typically as a tablet taken with or without food, according to the prescriber’s instructions. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically advised by a healthcare professional.

Serious adverse reactions, although rare, include cardiac arrhythmias, severe allergic responses (anaphylaxis), hepatotoxicity, extrapyramidal symptoms and hematologic abnormalities such as unexplained bruising or low blood counts. Patients should seek immediate medical attention if they experience any of these symptoms.

Oxomemazine is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. It should also be avoided in patients taking mono‑amine oxidase inhibitors (MAOIs) or those with conditions that could be exacerbated by its sedative or anticholinergic properties, unless directed by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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