Oxybuprocaine Hydrochloride Agepha 4 Mg/Ml (Oxybuprocaine Hydrochloride)

Oxybuprocaine hydrochloride is a topical ocular anesthetic that provides rapid surface numbness for eye examinations and minor procedures.

• Corneal abrasion assessment: facilitates painless examination of the cornea.
• Intra‑ocular pressure measurement: enables comfortable tonometry.
• Minor ocular surgery (e.g., foreign‑body removal): provides short‑lasting anesthesia.
• Diagnostic fluorescein staining: improves patient comfort during staining.
• Laser photocoagulation preparation: numbs the ocular surface before laser application.

• Oxybuprocaine hydrochloride blocks voltage‑gated sodium channels on peripheral sensory nerve endings in the cornea and conjunctiva, preventing depolarisation and the propagation of nerve impulses. This reversible inhibition produces rapid, localized loss of sensation without affecting deeper ocular structures.

Oxybuprocaine hydrochloride may cause transient ocular reactions following topical application.

Common Side Effects

• Burning or stinging sensation on instillation.
• Temporary blurred vision.
• Mild conjunctival hyperemia.
• Tearing or lacrimation.
• Foreign‑body sensation.

Serious or Rare Side Effects

• Corneal epithelial toxicity or ulceration.
• Persistent epithelial defect.
• Allergic contact dermatitis of the eyelid skin.
• Severe ocular inflammation.
• Vision loss (very rare).

When using Oxybuprocaine Hydrochloride Agepha, consider the following safety measures:

• Contraindication: Do not use in patients with known hypersensitivity to oxybuprocaine or related ester‑type anesthetics.
• Frequency: Limit applications to the number and interval recommended by the prescriber to avoid cumulative toxicity.
• Contact lenses: Advise patients to remove contact lenses before instillation and avoid re‑insertion until the drug is cleared.
• Monitoring: Observe for signs of corneal epithelial damage, especially with repeated use.
• Storage: Store at ambient temperature: keep in the original container, protect from light and moisture.

Oxybuprocaine hydrochloride may interact with other ophthalmic agents, potentially altering efficacy or safety.

Major Interactions (Avoid)

• Co‑administration with phenyl‑phen t t          ...  ....  ....  ... 

t  ....  t t t t t  t  t  t. Major Interaction (  t  t. t  t. t t. Moderate Interactions (Monitor Closely): -  t \