Oxycodon-Hcl/Naloxon-Hcl Mylan (Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Oxycodone Hydrochloride, the active ingredient in Oxycodon-Hcl/Naloxon-Hcl Mylan, is an opioid analgesic presented as a combination tablet for oral use. It is used to treat moderate to severe pain in adult patients when alternative treatments are inadequate. GNH India supplies Oxycodon-Hcl/Naloxon-Hcl Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Oxycodon-Hcl/Naloxon-Hcl Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Mylan Germany Gmbh

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Indications & Clinical Uses

Oxycodone‑naloxone combination products are used in the management of pain that requires opioid therapy, acting on the central nervous system to provide analgesia.

Chronic non‑cancer pain: provides sustained relief while reducing opioid‑induced constipation.
Cancer‑related pain: offers strong analgesia for breakthrough and background pain.
Post‑operative pain: helps control moderate to severe pain after surgery.
Acute traumatic injury pain: reduces pain intensity during the recovery period.
Palliative‑care pain: improves comfort in end‑of‑life settings.
Severe pain of any type where strong opioids are indicated for adults and cannot be controlled by other measures.

How It Works

The product combines oxy‑hydrochloride, a μ‑opioid receptor agonist that mimics endogenous opioids to inhibit pain transmission in the central nervous system, with naloxone hydrochloride, a peripheral opioid antagonist that limits gastrointestinal opioid effects. This dual action provides analgesia while reducing opioid‑related constipation by blocking peripheral receptors without diminishing central analgesic activity.

Side Effects

Oxycodone‑naloxone therapy can produce a range of adverse reactions, from mild to potentially life‑threatening.

Common Side Effects

Nausea: mild to moderate upset stomach.
Constipation: reduced bowel motility.
Dizziness: light‑headed sensation.
Somnolence: increased sleepiness.
Dry mouth: reduced salivation.
Pruritus: mild skin itching.

Serious or Rare Side Effects

Respiratory depression: slowed breathing that may be fatal.
Severe hypotension: marked drop in blood pressure.
Opioid dependence or withdrawal: signs of addiction or abrupt cessation effects.
Hepatic impairment: liver function abnormalities.
Allergic reactions: rash, swelling, or anaphylaxis.
adrenal insufficiency: abnormal cortisol production.

Precautions & Warnings

When using Oxycodone‑Naloxone, clinicians should assess patient risk factors and monitor for adverse events.

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Avoid Interactions

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Frequently Asked Questions

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 10 Oct 2026

Disclaimer

International sale not permitted. Listed for the domestic market and B2B only.

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