What is Oxycodon/Naloxon Develco used for?

Oxycodon/Naloxon Develco

Active Ingredient:: Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate
Origin:: EU

Oxycodon/Naloxon Develco (Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Oxycodone hydrochloride, the active ingredient in Oxycodon/Naloxon Develco, is an opioid analgesic presented as a combination tablet for oral use. It treats moderate to severe pain in adult patients when other analgesics are insufficient.
GNH India supplies Oxycodon/Naloxon Develco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Develco Pharma Gmbh

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Indications & Clinical Uses

Oxycodon/Naloxon Develco is an opioid analgesic used in the management of pain pathways associated with severe acute and chronic pain conditions.

Cancer‑related pain: Provides strong analgesia to improve functional comfort.
Post‑operative pain: Controls pain after major surgical procedures.
Chronic non‑cancer pain: Offers long‑term relief when other treatments have failed.
Severe traumatic injury pain: Reduces intense pain from serious injuries.
Palliative care pain: Enhances quality of life for patients in end‑of‑life care.

How It Works

Oxycodone binds to µ‑mu‑opioid receptors in the central nervous system, producing analgesia by inhibiting pain signal transmission. Naloxone, present in low oral doses, has limited systemic absorption but antagonizes µ‑receptor activation if the formulation is tampered with, reducing the risk of opioid‑induced respiratory depression.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

Constipation: Reduced gastrointestinal motility.
Nausea: Sensation of queasy stomach.
Drowsiness: Generalized sedation.
Dry mouth: Decreased salivary flow.
Dizziness: Light‑headed feeling, especially on standing.
Sweating: Increased perspiration.

Serious or Rare Side Effects

Respiratory depression: Marked reduction in breathing rate.
Severe hypotension: Dangerous drop in blood pressure.
Opioid dependence: Risk of physical and psychological addiction.
Hepatic dysfunction: Liver enzyme abnormalities.
Allergic reaction: Rash, itching, or anaphylaxis.
Seizures: Uncommon neurologic events.

Precautions & Warnings

When prescribing Oxycodon/Naloxon Develco, clinicians should consider several safety measures.

Assess pain severity: Confirm that opioid therapy is appropriate.
Review medical history: Identify respiratory, hepatic or renal impairment.
Monitor for dependence: Watch for signs of misuse or addiction.
Avoid abrupt discontinuation: Taper dose to prevent withdrawal.
Concomitant CNS depressants: Use with caution alongside benzodiazepines or alcohol.
Store below 25°C: Keep in the original packaging, protect from moisture and light.

Avoid Interactions

Oxycodon/Naloxon Develco can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

Benzodiazepines: Combined CNS depression increases risk of respiratory failure.
MAO inhibitors: May precipitate severe hypertension or serotonin syndrome.
CYP3A4 inhibitors (e.g., ketoconazole): Raise oxy‑cocaine [sic] plasma levels, heightening toxicity.

Moderate Interactions (Monitor Closely)

CYP2D6 inhibitors (e.g., fluoxetine): May reduce conversion of oxycodone to active metabolites.
Antihistamines: May enhance drowsiness and dizziness.
Diuretics: May exacerbate hypotension when combined with opioid‑induced vasodilation.

Frequently Asked Questions

Oxycodon/Naloxon Develco is a fixed‑dose combination of oxy‑

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 10 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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