Oxycodone/Naloxone Ratiopharm

Active Ingredient:: Naloxone, Oxycodone
Origin:: EU

Oxycodone/Naloxone Ratiopharm (Naloxone, Oxycodone)

International sale not permitted. Listed for the domestic market and B2B only.

Oxycodone, the active ingredient in Oxycodone/Naloxone Ratiopharm, is an opioid analgesic presented as a combination tablet for oral use. It is used to treat moderate to severe pain in adult patients when other treatments are insufficient. GNH India supplies Oxycodone/Naloxone Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Oxycodone/Naloxone Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Oxycodone/Naloxone is indicated for pain management within the opioid pathway, providing relief for several severe pain conditions.

Chronic cancer pain: Improves analgesia while reducing opioid‑induced constipation.
Post‑operative pain: Provides strong analgesic effect after major surgery.
Severe chronic non‑cancer pain: Offers sustained pain control when other opioids are inadequate.

How It Works

The combination pairs oxy‑an opioid receptor agonist that activates µ‑opioid receptors to produce analgesia, with naloxone, a peripheral opioid antagonist that blocks µ‑receptors in the gastrointestinal tract, reducing opioid‑induced constipation without diminishing central pain relief.

Side Effects

Adverse reactions may occur with Oxycodone/Naloxone use.

Common Side Effects

Nausea
Constipation
Dizziness
Headache
Dry mouth
Fatigue

Serious or Rare Side Effects

Respiratory depression
Severe hypotension
Seizures
Allergic reactions such as rash or angio‑angio‑edema
adrenal adrenal

Precautions & Warnings

When prescribing Oxycodone/Naloxone, clinicians should consider several safety measures.

Assess pain severity: Ensure the drug is appropriate for moderate to severe pain.
Monitor for respiratory depression: Watch for signs of slowed breathing, especially after dose changes.
Evaluate gastrointestinal function: Naloxone reduces constipation but monitor for bowel obstruction.
Check for drug dependence: Use caution in patients with a history of substance abuse.
Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Oxycodone/Naloxone can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

Concurrent use of other strong opioids: Increases risk of respiratory depression.
Benzodiazepines: Potentiates central nervous system depression.
MAO‑I inhibitors: May cause severe hypertension or serotonin syndrome.

Moderate --- ------

Frequently Asked Questions

Oxycodone/Naloxone Ratiopharm is an oral combination tablet used to treat moderate‑to‑severe pain, particularly when opioid‑induced constipation is a concern. It is commonly prescribed for chronic cancer pain, post‑operative pain and severe non‑cancer pain that has not responded adequately to other analgesics.

The formulation combines oxycodone, a µ‑opioid receptor agonist that provides central analgesia, with naloxone, a peripheral opioid antagonist that blocks µ‑receptors in the gut. This dual action maintains strong pain relief while reducing the constipation typically caused by opioids.

Dosing is individualized and set by the prescribing clinician based on the patient’s pain intensity, prior opioid exposure, renal and hepatic function, and overall health status. The prescriber determines the appropriate strength and dosing schedule.

Oxycodone/Naloxone is generally contraindicated during pregnancy because opioids can cause fetal dependence and neonatal withdrawal. It is also not recommended while breastfeeding, as oxycodone can pass into breast milk and affect the infant. Consultation with a specialist is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and necessary import documentation.

Compared with single‑agent opioids, Oxycodone/Naloxone offers comparable analgesic potency while actively reducing opioid‑induced constipation through the naloxone component. This can improve patient comfort and adherence, especially for long‑term therapy.

Store the tablets below 25 °C in the original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged.

The medication is taken orally, usually as a whole tablet, with or without food. Swallow the tablet whole; do not crush, chew or split it, as this may affect the intended release profile of the naloxone component.

The most serious risks include respiratory depression, severe hypotension, seizures and allergic reactions such as anaphylaxis. Patients should be monitored closely, especially during dose initiation or escalation.

Contraindications include patients with known hypersensitivity to oxycodone or naloxone, severe respiratory insufficiency, acute or severe asthma, paralytic ileus, and those taking MAO‑I inhibitors within 14 days. Caution is also advised for individuals with a history of substance abuse.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 10 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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