Oxycodone/Naloxone Sandoz (Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate)

Oxycodone/Naloxone combines an opioid agonist with an opioid antagonist to manage pain while reducing opioid‑induced constipation.

• Chronic non‑cancer pain: Provides effective analgesia for patients with long‑term severe pain.
• Cancer‑related pain: Controls moderate to severe pain associated with malignancies.
• Post‑operative pain: Offers short‑term relief after surgical procedures.
• Pain with opioid‑induced constipation risk: Balances pain relief with reduced risk of constipation in patients requiring strong opioids.

• Oxycodone activates µ‑mu‑opioid receptors in the central nervous system, producing analgesia, while naloxone has low oral bioavailability and acts locally in the gut to block µ‑receptors, mitigating opioid‑induced constipation without affecting central analgesic effects.

Side effects reflect both opioid activity and peripheral opioid antagonism.

Common Side Effects

• Nausea and vomiting
• Constipation (less severe than with pure opioid therapy)
• Dizziness
• Drowsiness
• Dry mouth
• Headache

Serious or Rare Side Effects

• Respiratory depression
• Severe hypotension
• Acute opioid withdrawal syndrome
• Hepatic impairment
• Allergic reactions such as rash or anaphylaxis
• Urinary retention

When prescribing Oxycodone/Naloxone, clinicians should consider several safety measures.

• Assess pain severity and opioid tolerance: Verify that the patient requires strong opioid therapy.
• Monitor for respiratory depression: Observe breathing, especially after dose initiation or increase.
• Evaluate liver and kidney function: Adjust dosing in hepatic or renal impairment.
• Avoid concurrent CNS depressants: Limit use of benzodiazepines or alcohol.
• Educate patients on constipation management: Provide guidance on diet, fluids, and laxatives.
• Store at ambient temperature: keep the tablet in the original pack and protect from moisture.

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