Oxycort (Hydrocortisone, Oxytetracycline Hydrochloride)

Oxycort is a dermatologic anti‑inflammatory and antibacterial agent that acts on skin lesions prone to infection and inflammation.

• Atopic dermatitis: reduces redness, itching and swelling associated with flare‑ups.
• Impetigo: eliminates Staphylococcus‑aureus and Streptococcus‑pyogenes bacteria, promoting lesion healing.
• Minor cuts and abrasions: prevents bacterial colonisation and eases local inflammation.

• Hydrocortisone binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, while oxytetracycline hydrochloride inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing bacterial growth and facilitating resolution of infection.

Adverse reactions may occur locally at the application site or systemically after extensive use.

Common Side Effects

• Burning or stinging sensation at the site of application.
• Mild skin irritation or erythema.
• Dryness or peeling of the treated skin.
• Pruritus (itching) unrelated to the underlying condition.

Serious or Rare Side Effects

• Contact dermatitis or allergic reaction with swelling and vesicle formation.
• Secondary skin infection due to over‑growth of non‑susceptible organisms.
• Systemic corticosteroid effects such as adrenal suppression with prolonged extensive use.
• Hypersensitivity anaphylaxis, though extremely rare.

When using Oxycort, consider the following safety measures:

• Apply sparingly: limit the amount to the smallest area needed to avoid systemic absorption.
• Duration of therapy: restrict use to the shortest period required for clinical improvement.
• Age restrictions: avoid use on extensive body surface areas in infants and young children.
• Concomitant skin products: do not combine with other potent topical steroids or occlusive dressings without medical advice.
• Monitor for infection: discontinue if signs of worsening bacterial infection appear.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Oxycort may interact with other topical or systemic agents that influence skin integrity or corticosteroid metabolism.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use can increase risk of systemic glucocorticoid effects.
• Potent topical antibiotics: may heighten local irritation or allergic responses.

Moderate Interactions (Monitor Closely)

• Antifungal agents: combined use can mask fungal infection signs.
• Immunosuppressants: may reduce host defence, increasing infection risk.
• Photosensitising drugs: heightened risk of phototoxic reactions on treated skin.