Oxykodon/Naloxon Sandoz (Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate)

Oxycodone/naloxone combines a potent opioid agonist with an antagonist to manage pain while reducing opioid‑induced constipation.

• Chronic cancer‑related pain: provides sustained relief for patients with persistent tumor‑associated pain.
• Post‑operative pain: controls moderate to severe pain after major surgical procedures.
• Severe non‑cancer chronic pain: offers long‑term analgesia for conditions such as severe osteoarthritis when other treatments are insufficient.
• Breakthrough pain episodes: allows supplemental dosing for sudden pain spikes in patients already on a stable opioid regimen.
• Palliative care: improves comfort and quality of life for patients with advanced disease requiring continuous pain control.

• Oxycodone binds to mu‑opioid receptors in the central nervous system, activating inhibitory pathways that diminish the perception of pain. Naloxone, present in a low systemic‑absorption ratio, antagonises opioid receptors in the gastrointestinal tract, counteracting opioid‑induced reduction of gut motility without compromising analgesia from oxy­codone.

Side effects may vary in frequency and severity.

Common Side Effects

• Nausea and vomiting: mild to moderate gastrointestinal upset.
• Constipation: reduced bowel motility common with opioid therapy.
• Dizziness or light‑headedness: transient sensation of imbalance.
• Somnolence: increased sleepiness, especially after dose initiation.
• Dry mouth: reduced salivation leading to a parched feeling.
• Pruritus: mild itching, often localized.

Serious or Rare Side Effects

• Respiratory depression: slowed breathing that can be life‑threatening.
• Severe hypotension: marked drop in blood pressure causing faintness.
• Opioid use disorder: risk of dependence with prolonged use.\n- Allergic reactions: rash, swelling, or anaphylaxis in susceptible individuals.
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