Oxypronal Lp

Active Ingredient:: Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate
Origin:: EU

Oxypronal Lp (Oxycodone Hydrochloride, Naloxone Hydrochloride Dihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Oxycodone Hydrochloride, the active ingredient in Oxypronal Lp, is an opioid analgesic presented as an oral formulation for systemic use. It is combined with naloxone hydrochloride dihydrate to mitigate opioid‑induced constipation and is prescribed for moderate to severe pain in adult patients. GNH India supplies Oxypronal Lp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Oxypronal Lp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Oxypronal Lp contains oxycodone, an opioid that acts on the central nervous system to relieve pain. It is indicated for:

Severe acute pain: provides rapid relief of intense pain following surgery or trauma.
Chronic cancer‑related pain: helps manage persistent pain associated with malignant disease.
Severe chronic non‑cancer pain: used when other analgesics are insufficient for conditions such as severe osteoarthritis.
Pain during palliative care: improves comfort for patients with end‑of‑life pain.
Post‑operative pain: reduces pain intensity after major surgical procedures.

How It Works

Oxycodone binds to mu‑opioid receptors in the central nervous system, producing analgesia by inhibiting the transmission of nociceptive signals. Naloxone, present in low oral bioavailability, antagonizes peripheral opioid receptors, reducing opioid‑induced gastrointestinal effects without diminishing central analgesia. The combined formulation therefore provides strong pain relief while limiting constipation.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

Nausea: mild to moderate upset stomach.
Constipation: reduced bowel movements.
Dizziness: feeling light‑headed or unsteady.
Somnolence: increased sleepiness.
Dry mouth: reduced salivation.
Pruritus: mild itching.

Serious or Rare Side Effects

Respiratory depression: slowed or shallow breathing.
Severe hypotension: marked drop in blood pressure.
Opioid dependence or withdrawal: signs of addiction.
Hepatic dysfunction: abnormal liver enzyme levels.
Anaphylaxis: severe allergic reaction.
Seizures: rare convulsive episodes.

Precautions & Warnings

When prescribing Oxypronal Lp, clinicians should consider several safety measures.

Assess pain severity and opioid tolerance before initiating therapy.
Monitor for signs of respiratory depression, especially in opioid‑naïve patients.
Evaluate liver and kidney function regularly, adjusting dose as needed.
Avoid concurrent use with other central nervous system depressants.
Counsel patients on the risk of dependence and proper disposal of unused tablets.
Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Oxypronal Lp can interact with a range of medicines, requiring careful management.

Major Interactions (Avoid)

Benzodiazepines: combined use can cause profound respiratory depression.
CNS depressants: additive sedation and impaired cognition.
MAO inhibitors: may precipitate severe hypertension or serotonin syndrome.

Moderate Interactions (Monitor Closely)

CYP3A4 inhibitors (e.g., ketoconazole): increase oxycodin plasma levels.
CYP3A4 inducers (e.g., rifampicin): reduce analgesic effect.
Anticholinergic agents: may worsen constipation.
Diuretics: can enhance hypotensive effects.
Serotonergic antidepressants: risk of serotonin syndrome when combined with high opioid doses.

Frequently Asked Questions

Oxypronal Lp is an oral combination of oxycodone and naloxone used to treat moderate to severe pain, including acute post‑surgical pain, chronic cancer‑related pain, and severe non‑cancer pain when other analgesics are insufficient.

Oxycodone activates mu‑opioid receptors in the brain and spinal cord, blocking pain signal transmission. Naloxone has low oral absorption and blocks peripheral opioid receptors, helping to reduce constipation without affecting central pain relief.

The specific dose of Oxypronal Lp is determined by the prescribing clinician based on the patient’s pain intensity, prior opioid exposure, and overall health status. Dosage adjustments are made individually and should follow local prescribing guidelines.

Oxypronal Lp is generally contraindicated in pregnancy and breastfeeding because opioids can affect fetal development and pass into breast milk, potentially causing respiratory depression in the newborn. Use only if the benefit outweighs the risk and under strict medical supervision.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with single‑ingredient opioids, Oxypronal Lp adds naloxone to reduce opioid‑induced constipation, offering a similar level of analgesia while improving gastrointestinal tolerability. It is often chosen when constipation is a major concern.

Store the tablets at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep out of reach of children and dispose of any unused product according to local regulations.

Oxypronal Lp is taken orally, usually with water. The tablet should be swallowed whole and not crushed or chewed, as altering the formulation can affect the balance between oxycodone and naloxone and increase the risk of side effects.

The most serious risks include respiratory depression, severe hypotension, opioid dependence, and rare but life‑threatening allergic reactions such as anaphylaxis. Immediate medical attention is required if any of these occur.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 11 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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