Product image of Ozurdex (Dexamethasone) supplied by GNH India

Ozurdex

Active Ingredient:
Dexamethasone
Origin:
EU

Ozurdex (Dexamethasone)

Dexamethasone, the active ingredient in Ozurdex, is a corticosteroid presented as a sustained‑release intravitreal implant for ocular use. It is indicated for the treatment of macular edema secondary to retinal vein occlusion, diabetic macular edema, and non‑infectious uveitis in adult patients. GNH India supplies Ozurdex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and ophthalmology clinics worldwide.

GNH India supplies Ozurdex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and ophthalmology clinics worldwide.

Manufacturer / TM Owner

Abbvie Ltd (Uk)

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Indications & Clinical Uses

Ozurdex is a corticosteroid implant used to manage inflammatory and vascular eye conditions that cause macular swelling.

  • Macular edema secondary to retinal vein occlusion: reduces fluid accumulation and improves visual acuity.
  • Diabetic macular edema: decreases retinal swelling and stabilises vision.
  • Non‑infectious uveitis affecting the posterior segment: controls intra‑ocular inflammation and limits vision loss.

How It Works

  • Dexamethasone released from the Ozurdex implant binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, reduce vascular permeability, and inhibit leukocyte migration. This anti‑inflammatory and anti‑edematous activity lessens retinal swelling and stabilises the blood‑retinal barrier.

Side Effects

Ozurdex may cause ocular and systemic adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Elevated intra‑ocular pressure: transient rise after implantation.
  • Cataract formation: accelerated lens opacity with repeated exposure.
  • Conjunctival hyperemia: redness around the injection site.
  • Floaters: visual disturbances from implant particles.
  • Vitreous hemorrhage: minor bleeding during or after procedure.

Serious or Rare Side Effects

  • Endophthalmitis: intra‑ocular infection requiring urgent treatment.
  • Retinal detachment: separation of retinal layers.
  • Persistent elevated intra‑ocular pressure requiring surgery.
  • Severe cataract necessitating extraction.
  • Implant migration to the anterior chamber.
  • Vision loss not attributable to underlying disease.

Precautions & Warnings

Before using Ozurdex, clinicians should assess ocular health and systemic risk factors.

  • Monitor intra‑ocular pressure: check regularly after implantation.
  • Evaluate for glaucoma history: patients with uncontrolled glaucoma may be unsuitable.
  • Assess lens status: pre‑existing cataract may progress faster.
  • Avoid in active ocular infection: implantation can worsen infection.
  • Use caution in patients on systemic steroids: additive pressure‑raising effect possible.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ozurdex may interact with other ocular or systemic therapies that influence intra‑ocular pressure or inflammation.

Major Interactions (Avoid)

  • Concurrent intravitreal anti‑VEGF agents: may increase risk of ocular hypertension.
  • Systemic corticosteroids: additive effect on intra‑ocular pressure.

Moderate Interactions (Monitor Closely)

  • Topical ocular steroids: monitor pressure if used together.
  • Antiglaucoma medications: dose adjustments may be needed.
  • Anticoagulants: may increase risk of vitreous hemorrhage during implantation.
  • NSAIDs: may affect wound healing post‑procedure.
  • Immunosuppressants: heightened infection risk, monitor closely.

Frequently Asked Questions

Ozurdex is an intravitreal implant that delivers dexamethasone directly to the eye. It is approved for treating macular edema caused by retinal vein occlusion, diabetic macular edema, and non‑infectious posterior segment uveitis in adult patients.

Dexamethasone binds to glucocorticoid receptors inside ocular cells, suppressing inflammatory cytokines and reducing vascular leakage. This anti‑inflammatory action decreases retinal swelling and helps maintain the blood‑retinal barrier.

Ozurdex is supplied as a single‑use, sustained‑release implant that is inserted by an ophthalmologist. The prescribing clinician determines the need for repeat implantation based on the patient’s response and disease activity.

Safety data for intravitreal dexamethasone implants in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the Ozurdex product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ozurdex provides a sustained‑release corticosteroid effect, reducing the need for frequent injections compared with short‑acting anti‑VEGF agents. It is particularly useful when inflammation contributes to edema, but it may carry a higher risk of intra‑ocular pressure rise and cataract formation.

Ozurdex should be stored at ambient temperature, protected from moisture and direct sunlight, and kept in its original packaging until use. Do not expose the implant to extreme temperatures or mechanical stress.

Ozurdex is implanted into the vitreous cavity of the eye using a specially designed applicator. The procedure is performed by a qualified ophthalmologist in a sterile setting, typically under local anaesthesia.

Serious risks include elevated intra‑ocular pressure that may require surgical intervention, endophthalmitis, retinal detachment, and significant cataract progression. Patients should be monitored closely for these complications after implantation.

Ozurdex is contraindicated             

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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