Product image of Pabal (Carbetocin) supplied by GNH India

Pabal

Active Ingredient:
Carbetocin
Origin:
EU

Pabal (Carbetocin)

Carbetocin, the active ingredient in Pabal, is an oxytocin analog presented as a sterile injectable solution for intravenous use. It is used to prevent postpartum hemorrhage in women after vaginal delivery or caesarean section. GNH India supplies Pabal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

GNH India supplies Pabal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

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Indications & Clinical Uses

Carbetocin is employed in obstetric care to promote uterine contraction and reduce bleeding.

  • Postpartum hemorrhage: Helps reduce the incidence of excessive bleeding after vaginal delivery.
  • Caesarean section recovery: Supports uterine tone following surgical birth.
  • Uterine atony: Assists in restoring uterine muscle tone when it is insufficient after delivery.

How It Works

  • Carbetocin binds to oxytocin receptors on uterine smooth muscle, mimicking the action of endogenous oxytocin. This activation triggers intracellular calcium release, leading to sustained uterine contractions that compress blood vessels and reduce postpartum bleeding.

Side Effects

Adverse reactions to carbetocin are generally mild to moderate and reflect its uterotonic activity.

Common Side Effects

  • Nausea: Mild, transient nausea may occur.
  • Headache: Occasional mild headache.
  • Flushing: Temporary skin flushing.
  • Hypertension: Slight increase in blood pressure.
  • Tachycardia: Mild increase in heart rate.

Serious or Rare Side Effects

  • Anaphylaxis: Severe allergic reaction requiring immediate medical attention.
  • Myocardial ischemia: Chest pain or cardiac ischemia in susceptible individuals.
  • Pulmonary edema: Fluid accumulation in the lungs.
  • Seizures: Rare neurologic events.
  • Severe hypotension: Marked drop in blood pressure.

Precautions & Warnings

When using carbetocin, clinicians should assess patient history and monitor vital signs.

  • Contraindications: Known allergy to carbetocin or oxytocin.
  • Cardiovascular monitoring: Observe blood pressure and heart rate during administration.
  • Fluid balance: Ensure adequate hydration to avoid hypotension.
  • Pre‑eclampsia/eclampsia: Use with caution in patients with these conditions.
  • Store at ambient temperature: Keep in original packaging, protect from light and moisture.

Avoid Interactions

Carbetocin may interact with other agents that affect cardiovascular function or uterine activity.

Major Interactions (Avoid)

  • Vasopressors: May exacerbate hypertension when combined.
  • Beta‑blockers: Can blunt heart‑rate response.
  • Magnesium sulfate: May potentiate uterine relaxation, reducing efficacy.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: May require dose adjustment of carbetocin.
  • Diuretics: Can influence fluid status and blood pressure.
  • Anesthetic agents: May alter hemodynamic response during surgery.

Frequently Asked Questions

Pabal contains carbetocin, which is used in obstetric practice to prevent postpartum hemorrhage by promoting sustained uterine contractions after vaginal delivery or caesarean section.

Carbetocin acts as an oxytocin receptor agonist on uterine smooth muscle, triggering calcium‑mediated contractions that help compress uterine blood vessels and reduce bleeding after childbirth.

The prescribed dose of Pabal is determined by the treating clinician based on the patient’s condition, delivery method and clinical guidelines. Specific dosing information should be obtained from a qualified healthcare professional.

Carbetocin is administered after delivery to manage postpartum bleeding, so it is not used during pregnancy. Safety during breastfeeding has not been established; clinicians should evaluate risks and benefits for each patient.

To order Pabal, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Carbetocin offers a longer half‑life than oxytocin, providing sustained uterine contraction with a single dose, which can reduce the need for repeat dosing. It is considered comparable in efficacy to other uterotonics such as methylergometrine, with a different safety profile.

Pabal should be stored at ambient temperature, below 25 °C, in its original packaging, protected from light and moisture to maintain stability.

Pabal is supplied as a sterile injectable solution and is administered intravenously or intramuscularly by a qualified healthcare professional immediately after delivery, following aseptic technique.

Serious risks include severe allergic reactions such as anaphylaxis, myocardial ischemia, pulmonary edema, seizures, and marked hypotension. Prompt medical intervention is required if any of these events occur.

Pabal should not be used in individuals with a known hypersensitivity to carbetocin or oxytocin, or in patients where uterine contraction is contraindicated, such as certain cases of cardiovascular instability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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