Paduden Express (Ibuprofen)

Ibuprofen is an NSAID that reduces inflammation and pain across several common conditions.

• Headache: provides relief from mild to moderate tension‑type headaches.
• Dental pain: helps manage postoperative dental discomfort.
• Musculoskeletal pain: reduces pain and swelling associated with sprains, strains and minor injuries.
• Fever: lowers elevated body temperature in febrile adults and children.
• Menstrual cramps: eases dysmenorrhea‑related pelvic pain.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. This reduction in prostaglandin levels underlies its analgesic, antipyretic and anti‑inflammatory actions.

Adverse reactions to ibuprofen vary in frequency and severity.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain.
• Headache: transient headache may occur.
• Dizziness: occasional light‑headedness.
• Rash: mild skin redness or itching.
• Elevated blood pressure: slight increase in some patients.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe allergic reactions: anaphylaxis, angioedema.
• Liver injury: marked elevation of hepatic enzymes.
• Kidney impairment: acute renal failure, especially with dehydration.
• Cardiovascular events: increased risk of heart attack or stroke.

Before using Paduden Express, consider the following safety measures:

• Assess gastrointestinal risk: avoid in patients with active ulcers or severe dyspepsia.
• Evaluate cardiovascular health: use cautiously in those with hypertension or heart disease.
• Monitor renal function: contraindicated in severe kidney impairment.
• Check for drug allergies: avoid if known hypersensitivity to ibuprofen or other NSAIDs.
• Pregnancy and lactation: limit use to the lowest effective duration and consult a healthcare professional.
• Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture.

Ibuprofen can affect the activity of several other medicines. Review the following interaction categories:

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• High‑dose aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors (e.g., celecoxib): additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihyant antihypertensive effect.
• Diuretics: risk of reduced renal perfusion.
• Lithium: increased serum lithium levels.
• Methotrexate: decreased renal clearance leading to toxicity.
• SSRIs: elevated risk of gastrointestinal bleeding.