Paduden (Ibuprofen)

Ibuprofen acts on inflammatory pathways to provide analgesic and antipyretic effects.

• Mild to moderate pain: reduces pain intensity in conditions such as headache, dental pain, and musculoskeletal aches.
• Fever: lowers elevated body temperature in febrile states.
• Inflammatory disorders: diminishes swelling and discomfort in conditions like osteoarthritis and rheumatoid arthritis.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis lowers inflammation, pain signalling and fever generation throughout the body.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or heartburn.
• Headache: mild to moderate intensity.
• Dizziness or light‑headedness.
• Rash or mild skin irritation.
• Elevated blood pressure: transient increases.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Hepatotoxicity or elevated liver enzymes.
• Anaphylaxis or severe allergic reactions.

When using Paduden, consider several safety measures to minimise risks.

• Assess renal function: evaluate patients with pre‑existing kidney disease.
• Monitor gastrointestinal health: avoid use in patients with active ulcers or a history of GI bleeding.
• Evaluate cardiovascular risk: use cautiously in individuals with hypertension or heart disease.
• Review concomitant medications: check for other NSAIDs or anticoagulants.
• Pregnancy and breast‑feeding: consult the appropriate clinical guidelines for risk assessment.
• Store at ambient temperature: keep the tablet in the original pack and protect from moisture.

• Ibuprofen may interact with several medicines, altering efficacy or safety.
• Major Interaction : 
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