Pafinur (Rupatadine)

Rupatadine is an antihistamine that works on the histamine‑mediated allergic pathway.

• Allergic rhinitis: reduces nasal congestion, itching and sneezing.
• Chronic spontaneous urticaria: lessens wheal formation and itching.
• Seasonal allergy symptoms: alleviates eye and throat irritation associated with pollen exposure.

• Rupatadine blocks histamine H1 receptors and antagonizes platelet‑activating factor (PAF) receptors, preventing the release of inflammatory mediators that cause the symptoms of allergic reactions. This dual antagonism reduces vascular permeability, itching and other histamine‑driven responses.

Rupatadine may cause a range of adverse reactions.

Common Side Effects

• Drowsiness: mild to moderate sedation.
• Dry mouth: reduced salivation.
• Headache: tension‑type headache.
• Gastrointestinal discomfort: nausea or mild abdominal pain.
• Fatigue: feeling of tiredness.

Serious or Rare Side Effects

• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Anaphylaxis: acute, potentially life‑threatening allergic response.
• Cardiac arrhythmias: irregular heart rhythm.
• Hepatotoxicity: elevated liver enzymes.
• Hematologic abnormalities: thrombocytopenia or neutropenia.

Before using Pafinur, consider the following safety measures:

• Assess risk of sedation: patients should avoid driving or operating heavy machinery while experiencing drowsiness.
• Review medical history for cardiovascular conditions :  
• Evaluate the possible interaction with alcohol : 
• Check the presence of renal or the  
• Store at below 25°C: keep the tablet in the original pack and protect from moist 

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