Paidofen (Ibuprofen)

Paidofen is an NSAID that acts on inflammatory pathways to relieve several common conditions.

• Headache: reduces pain intensity and improves functional ability.
• Dental pain: alleviates postoperative and procedural discomfort.
• Musculoskeletal pain: decreases inflammation‑related soreness in joints and muscles.
• Fever: lowers elevated body temperature.
• Dysmenorrhea: eases menstrual cramps and associated pain.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate pain, fever and inflammation. This reduction in prostaglandin levels dampens peripheral nociceptor sensitisation and lowers the hypothalamic set‑point for temperature regulation.

Adverse reactions to ibuprofen may range from mild to severe.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or heartburn.
• Headache: mild, transient headache.
• Dizziness: occasional light‑headed feeling.
• Rash: mild skin redness or itching.
• Fluid retention: mild peripheral oedema.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Hepatotoxicity: elevated liver enzymes or hepatitis.
• Anaphylaxis: life‑threatening allergic reaction.

When using Paidofen, consider the following safety measures:

• Assess renal function: check baseline kidney parameters in patients with existing kidney disease.
• Evaluate cardiovascular risk: use caution in individuals with hypertension or heart disease.
• Review gastrointestinal history: avoid in patients with active ulcers or a history of significant GI bleeding.
• Monitor for asthma exacerbation: ibuprofen can trigger bronchospasm in aspirin‑sensitive individuals.
• Avoid use in late pregnancy: third‑trimester exposure may affect fetal cardiovascular function.
• Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Ibuprofen may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity.
• Selective COX‑2 inhibitors (e.g., celecoxib): heightened cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect.
• Diuretics: may diminish diuretic‑induced natriuresis.
• Lithium: ibuprofen can raise serum lithium concentrations.
• Methotrexate: reduced renal clearance may increase toxicity.
• Corticact