Palbace 125mg (Palbociclib) 125mg

Palbace 125mg is a CDK4/6 inhibitor used to treat certain types of breast cancer.

• Hormone receptor-positive, HER2-negative advanced breast cancer: Used in combination with hormonal anticancer therapies to treat breast cancer that has spread to other organs.
• Hormone receptor-positive, HER2-negative metastatic breast cancer: Used to slow the progression of cancer that has spread to other parts of the body.
• Postmenopausal women with breast cancer: Specifically indicated for postmenopausal women with hormone receptor-positive, HER2-negative breast cancer.

• Palbace 125mg works by selectively inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in the regulation of the cell cycle. By inhibiting CDK4/6, Palbace 125mg causes G1-phase cell-cycle arrest in tumor cells, preventing the proliferation of cancer cells and slowing the growth of the tumor.

Palbace 125mg may cause several side effects, ranging from common to serious.

Common Side Effects

• Fatigue: Feeling tired or weak.
• Hair loss: Alopecia or thinning of hair.
• Rash: Skin irritation or redness.
• Vomiting: Feeling nauseous or vomiting.
• Diarrhea: Frequent loose or watery stools.
• Dizziness: Feeling lightheaded or unsteady.

Serious or Rare Side Effects

• Infection: Increased susceptibility to infections due to reduced blood cell counts.
• Bleeding or bruising: Unusual bleeding or bruising due to low blood cell counts.
• Fever or chills: Signs of infection that should be reported to a doctor immediately.
• Heart problems: Potential cardiac issues that should be monitored closely.

Palbace 125mg should be used with caution and under medical supervision.

• Inform your doctor: Tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections.
• Avoid pregnancy: This medicine is not recommended during pregnancy or while breastfeeding. Use effective contraception to avoid pregnancy.
• Monitor blood cell counts: Regularly monitor blood cell counts to detect any reductions in red or white blood cells.
• Avoid driving: Dizziness may impair your ability to drive or perform tasks requiring alertness.
• Store below 25°C: Keep in the original pack, protect from moisture.

Palbace 125mg may interact with other medications, which can affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

• Strong CYP3A inhibitors: Avoid concomitant use as it can increase the concentration of Palbociclib.
• Strong CYP3A inducers: Avoid concomitant use as it can decrease the concentration of Palbociclib.
• Antibiotic medications: Avoid concomitant use as it can affect the efficacy of Palbace 125mg.

Moderate Interactions (Monitor Closely)

• Other anticancer medications: Monitor closely as they can increase the risk of side effects.
• Medications affecting blood cell counts: Monitor blood cell counts regularly.
• Medications affecting liver function: Monitor liver function regularly.