Product image of Palexia (Tapentadol) supplied by GNH India

Palexia

Active Ingredient:
Tapentadol
Origin:
EU

Palexia (Tapentadol)

Tapentadol, the active ingredient in Palexia, is an opioid analgesic presented as a strength/form for oral use. It is indicated for the management of moderate to severe acute pain in adult patients when alternative treatments are inadequate. GNH India supplies Palexia as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Palexia as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grünenthal Gmbh

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Indications & Clinical Uses

Tapentadol is an opioid analgesic that acts on the central nervous system to relieve pain.

  • Acute postoperative pain: Provides effective analgesia following surgical procedures.
  • Chronic musculoskeletal pain: Helps manage persistent pain associated with conditions such as osteoarthritis.
  • Cancer‑related pain: Used as part of a multimodal regimen for cancer pain management.
  • Neuropathic pain: May reduce pain intensity in certain neuropathic pain syndromes.
  • Severe traumatic injury pain: Controls pain after major trauma.

How It Works

  • Tapentadol exerts its analgesic effect through a dual mechanism: it is a μ‑opioid receptor agonist that activates opioid pathways and simultaneously inhibits norepinephrine reuptake, enhancing descending inhibitory pain signals in the central nervous system. This combined action reduces the perception of pain without requiring high opioid receptor occupancy alone.

Side Effects

Tapentadol may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea
  • Constipation
  • Dizziness
  • Headache
  • Somnolence
  • Dry mouth

Serious or Rare Side Effects

  • Respiratory depression
  • Seizures
  • Severe hypotension
  • Anaphylaxis
  • Addison Syndrome
  • Stevens‑Stevens ":"    "  """"  """ """

Precautions & Warnings

  • Tapentadol may  
  • g  
  • t  \

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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