Product image of Paliperidona Teva (Paliperidone) supplied by GNH India

Paliperidona Teva

Active Ingredient:
Paliperidone
Origin:
EU

Paliperidona Teva (Paliperidone)

Paliperidone, the active ingredient in Paliperidona Teva, is an atypical antipsychotic presented as a tablet for oral use. It is prescribed for the treatment of schizophrenia and related psychotic disorders in adults.
GNH India supplies Paliperidona Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma – Produtos Farmacêuticos Lda

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Indications & Clinical Uses

Paliperidone is used in the management of psychotic disorders, primarily acting on dopamine and serotonin pathways.

  • Schizophrenia: reduces positive and negative symptoms and helps maintain stability.
  • Schizoaffective disorder: controls both mood and psychotic symptoms.
  • Maintenance treatment of schizophrenia: prevents relapse and recurrence of psychotic episodes.

How It Works

  • Paliperidone, the active metabolite of risperidone, exerts its antipsychotic effect by antagonizing dopamine D2 and serotonin 5‑HT2A receptors, while also blocking alpha‑1 adrenergic and histamine H1 receptors. This receptor profile modulates neurotransmission, reducing psychotic symptoms and stabilising mood.

Side Effects

Paliperidona Teva may cause a range of adverse reactions.

Common Side Effects

  • Weight gain: increase in body mass index.
  • Somnolence: feeling unusually sleepy.
  • Akathisia: inner restlessness and urge to move.
  • Extrapyramidal symptoms: muscle stiffness or tremor.
  • Elevated prolactin: menstrual changes or galactorrhea.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and rigidity.
  • Tardive dyskinesia: persistent involuntary movements.
  • Severe orthostatic hypotension: marked drop in blood pressure on standing.
  • Seizures: convulsive episodes.
  • Agranulocytosis: dangerously low white‑blood‑cell count.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor weight: assess body weight regularly.
  • Check blood glucose: screen for hyperglycaemia.
  • Evaluate lipid profile: monitor cholesterol and triglycerides.
  • Observe for extrapyramidal symptoms: watch for movement disorders.
  • Measure prolactin levels: detect hormonal disturbances.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paliperidona Teva can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase paliperidone exposure.
  • Potent CYP3A4 inducers (e.g., rifampin): may reduce efficacy.
  • QT‑prolonging agents (e.g., certain antiarrhythmics): increase risk of cardiac arrhythmia.

Moderate Interactions (Monitor Closely):\n- CNS depressants (e.g., alcohol, benzodiazepines): enhance sedation.

  • Antihypertensive drugs: may exacerbate orthostatic hypotension.
  • Medications affecting prolactin (e.g., metoclopramide): can amplify hormonal side effects.

Frequently Asked Questions

Paliperidona Teva contains paliperidone, which is indicated for the treatment of schizophrenia, schizoaffective disorder, and for maintenance therapy to prevent relapse of schizophrenia in adult patients.

Paliperidone blocks dopamine D2 and serotonin 5‑HT2A receptors, reducing excess dopamine activity that contributes to psychotic symptoms, while also influencing other neurotransmitter pathways to stabilise mood.

The prescribed dose of Paliperidona Teva is determined by the treating physician based on the individual’s clinical condition, response, and tolerability. Patients should follow the prescriber’s instructions exactly.

Paliperidone should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers must evaluate each case carefully.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Paliperidona Teva is the active metabolite of risperidone and offers a similar receptor profile but with a longer half‑life, allowing once‑daily dosing. Compared with older antipsychotics, it generally has a lower risk of certain motor side effects but still requires monitoring for metabolic changes.

Store the tablets at room temperature, below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children.

Paliperidona Teva is taken orally, usually once daily with or without food, as directed by the prescribing clinician. Swallow the tablet whole with water; do not crush or chew unless specifically instructed.

Serious risks include neuroleptic malignant syndrome, tardive dyskinesia, severe orthostatic hypotension, seizures, and agranulocytosis. Patients should be educated to seek immediate medical attention if they experience fever, muscle rigidity, uncontrolled movements, or signs of infection.

Paliperidona Teva is contraindicated in patients with known hypersensitivity to paliperidone or any component of the formulation, and in individuals with severe central nervous system depression. Caution is advised for patients with cardiovascular disease, uncontrolled diabetes, or a history of seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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