Product image of Palonosetron Fresenius Kabi (Palonosetron Hydrochloride) supplied by GNH India

Palonosetron Fresenius Kabi

Active Ingredient:
Palonosetron Hydrochloride
Origin:
EU

Palonosetron Fresenius Kabi (Palonosetron Hydrochloride)

Palonosetron Hydrochloride, the active ingredient in Palonosetron Fresenius Kabi, is a selective 5‑HT3 receptor antagonist presented as a sterile injectable solution for intravenous use. It is employed to prevent chemotherapy‑induced nausea and vomiting in adult cancer patients.
GNH India supplies Palonosetron Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Fresenius Kabi S.R.O.

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Indications & Clinical Uses

Palonosetron Fresenius Kabi is a 5‑HT3 antagonist used in the management of nausea and vomiting associated with chemotherapy and related triggers.

  • Chemotherapy‑induced nausea and vomiting (CINV): Provides effective prophylaxis before the start of highly emetogenic chemotherapy.
  • Post‑operative nausea and vomiting (PONV): Reduces the incidence of nausea and vomiting after surgical procedures requiring anesthesia.
  • Radiotherapy‑induced nausea and vomiting: Helps control nausea associated with radiation treatment of the abdomen or pelvis.
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How It Works

  • Palonosetron binds with high affinity to the 5‑HT3 receptors located on vagal afferent nerves in the gastrointestinal tract and the chemoreceptor trigger zone of the brain. By blocking these serotonin receptors, it prevents the initiation of the emetic signaling cascade, thereby reducing both acute and delayed phases of chemotherapy‑induced nausea and vomiting.

Side Effects

Palonosetron, like other 5‑HT3 antagonists, may cause a range of adverse reactions.

Common Side Effects

  • Headache 
  • Constipation 
  • Fatigue 
  • Diarrhea 
  • Dizziness

Serious or Rare Side Effects

  • QT‑interval prolongation
  • Severe hypersensitivity reactions (anaphylaxis, angio‑angelf )
  • Serotonin syndrome 
  • Cardiac arrhythmia 
  • Pulmonary edema 

Precautions & Warnings

When using Palonosetron Fresenius Kabi, clinicians should consider several safety aspects.

  • Cardiac monitoring: Assess 

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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