Product image of Palonosetron Kalceks (Palonosetron) supplied by GNH India

Palonosetron Kalceks

Active Ingredient:
Palonosetron
Origin:
EU

Palonosetron Kalceks (Palonosetron)

Palonosetron, the active ingredient in Palonosetron Kalceks, is a 5‑HT3 receptor antagonist presented as a 0.075 mg/2 ml solution for intravenous use. It is used to prevent nausea and vomiting associated with chemotherapy and postoperative settings in adult patients. GNH India supplies Palonosetron Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

GNH India supplies Palonosetron Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Palonosetron Kalceks is a 5‑HT3 receptor antagonist indicated for several clinical situations involving nausea and vomiting.

  • Chemotherapy‑induced nausea and vomiting (CINV): Provides prophylaxis against acute and delayed CINV in adult patients receiving moderately to high‑emetogenic chemotherapy.
  • Post‑operative nausea and vomiting (PONV): Reduces the incidence of nausea and vomiting after surgical procedures requiring general anesthesia.
  • Radiotherapy‑induced nausea and vomiting: Helps prevent the onset of nausea and vomiting during radiation treatment.
  • Antiemetic prophylaxis for patients receiving highly high dose stem cell transplant conditioning regimens.

How It Works

  • Palonosetron selectively binds to the 5‑HT3 receptors on vagal afferent nerves in the gastrointestinal tract and the chemoreceptor trigger zone. By blocking serotonin from activating these receptors, it prevents the neural signaling that triggers the vomiting reflex, offering prolonged anti‑emetic protection that lasts up to 72 hours after a single dose.

Side Effects

Palonosetron is generally well‑tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache 
  • Constipation 
  • Fatigue 
  • Diarrhoea 
  • Dizziness

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) 
  • QT‑interval prolongation 
  • Serotonin syndrome 
  • Cardiac arrhythmias 
  • Persistent severe constipation (obstruction).

Precautions & Warnings

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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